Research Interests
The domain of specialization is Biotechnology and the fields of Bioprocessing (emphasis on Affinity Interactions), de novo Design of artificial receptors, Combinatorial Chemistry and Nanobiotechnology.
Current research projects focus on:
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Affinity interactions between natural partners and between biomolecules and artificial receptors. Study of molecular interactions for the development of biomimetic ligands to purify and detect biomolecules with potential biotechnological interest.
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Synthesis of solid-phase combinatorial libraries in miniaturised formats.
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Biosensors; Detection of molecular interactions and selection of binding partners.
Main publications
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Roque, A.C.A., Lowe, C.R., Taipa, M.A. (2004), "Antibodies and Genetically Engineered Related Molecules: Production and Purification”, Biotechnology Progress, 20: 639-654.
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Roque, A.C.A., Taipa, M.A., Lowe, C.R. (2005), "An artificial Protein L for the purification of immunoglobulins and Fab fragments by affinity chromatography”, Journal of Chromatography A, 1064: 157-167.
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Barroso, TG, Temtem, M., Hussain, A., Aguiar-Ricardo, A., Roque, A.C.A.* (2010), "Preparation of a green cellulose-based affinity membrane for antibody purification", Journal of Membrane Science, 348 (1-2): 224-230.
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Batalha, I.L., Hussain, A., Roque, A.C.A.* (2010) "Gum Arabic coated magnetic nanoparticles with affinity for antibodies", Journal of Molecular Recognition, 23: 462-471.
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Dias AM, Marcos AS, Hussain A, Roque ACA (2011), "A biotechnological perspective on the application of iron oxide magnetic colloids modified with polysaccharides”, Biotechnology Advances, 29: 142-155.
Contacts
Ana Cecília Roque
REQUIMTE/CQFB Departamento de Química,
Faculdade de Ciências e Tecnologia, Univ. Nova de Lisboa
2829-516 Caparica, Portugal
Phone: (+351) 212 948 300
Ext;10985