The main activities include:
Isolation of functional ingredients from several botanical sources. Efficient clean processes are optimized for the extraction of natural high added-value products (antioxidants, anti-inflammatory, anti-cancer compounds, anti-fungal and anti-microbial agents) from solid or liquid materials.
Chemical and biological characterization of functional products: in-depth sample analysis, determination of antioxidant capacity (e.g. total phenolics content, ORAC and HORAC values, inhibition of AAPH-induced LDL oxidation.) and determination of (physiological) anti-inflammatory activity. The biological properties of the active components are assessed at cellular level in appropriate cell lines searching for protection responses to environmental stresses and cell death signals.
Formulation of new products by incorporation of high value natural extracts, with application in food, nutraceutical and and cosmeceutical industries. Optimization of final formulations in terms of stability/shelf-life, solubility/ bioavailability and compatibility with target final products.
Encapsulation and micronization of active compounds using non conventional techniques. Supercritical Fluid technology has been shown to be a viable option with relevant advantages like the use of mild conditions for pharmaceutical processing, minimization of organic solvent and use of environmentally benign nontoxic materials, and production of smaller particles with controllable morphology and narrow size distribution. Also, the unique solvent tuneability of supercritical fluids, from gas-like to liquid-like properties, offers the intriguing possibility of precise control over the processing conditions. Several forms using lipids and/or (biocompatible and/or biodegradable) polymers as carrier materials, have been successfully prepared.
For further information please visit ITQB laboratory's website