Research Projects

NETDIAMOND: New targets in diastolic heart failure: from comorbidities to personalized medicine
20162019, POCI-01-0145-FEDER-016385

Ongoing International Funded Projects

DiViNe - Sustainable Downstream Processing of Vaccines through Incorporation of Nanobiotechnology: Novel Affinity Ligands and Biomimetic Membranes
20152020, H2020-BIOTEC-2014-2015/H2020-LEIT-BIO-2014-1-635770. Funded by the EU.

INNOVATE - Investigating Novel Valuable bio-therapeutics and expression systems
20142017, ERA-IB-2/0007/2013

EDUFLUVAC – Combinatorial immunization strategy to educate the immune system towards cross recognition and coverage against antigenic drift in seasonal influenza virus exposure
20132017, FP7-HEALTH-2013-INNOVATION. Funded by the EU.

Ongoing National Funded Projects

ERAdicatPH: Understanding primary hyperoxaluria type 1 towards the development of innovative therapeutic strategies
20162019, E-Rare3/0002/2015, funded by FCT, Portugal

Therapeutic Targets for Triple Negative Breast Cancer: Development of mono and bispecific antibodies against Notch1 ligands
20162019, PTDC/BBB-BMD/4497/2014, funded by FCT, Portugal

CardioRegen: Integrative studies from the embryo to Scalable Multipronged Generation of hESC-derived Myocardial progenitors for heart repair

CardioStem: Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications
20142017, MIT-TB/ECE/0013/2013, funded by FCT, Portugal

Projects with Industry

Over the past 20 years, a wide range of R&D projects have been carried out for several pharmaceutical companies, biotech SMEs and academic institutions.

Concluded projects (International Funding)

EPIGENESIS – One Health approach to integrate Guadeloupe research on vector-borne and emerging diseases in the ERA
20132016, FP7-REGPOT-2012-2013-1, funded by the EU.

BRAINVECTORS— From Brain Gene Transfer Towards Gene Therapy: Pharmacological Assessment of AAV, CAV and LVV
20122016, FP7-PEOPLE-2011-IAPP. Funded by the EU.

SpeCCC - Specialised Cell Carrier Components
20122014, FP7‐SME‐2012‐315717, funded by the EU

NanoGene - Stem cell generation and manipulation by nanoparticle mediated gene transfer for the safe clinical application of gene-modified cells
20112014, ENMED/0001/2010, funded by EuroNanoMed ERA-Net.

ComplexINC - New Technologies and Production Tools for Complex Protein Biologics.
20112015, FP7 / SME-targeted research for developing tools and technologies for high-throughput research, funded by EU.

PREDECT – New Models for Preclinical Evaluation of Drug Efficacy in common solid tumours
20112016, GRANT AGREEMENT No. 115188, funded by IMI (Innovative Medicines Initiative) Joint Undertaking, funded by EU.

CAREMI - Cardio Repair European Multidisciplinary Initiative
20102015, HEALTH-F5-2010-242038, funded by EU

HYPERLAB - high yield and performance stem cell lab
20092012, funded by EU (223011)

BrainCAV: Gene Transfer for Brain Therapy
20082012, funded by EU (FP7-222992)

CLINIGENE-NoE: European Network for the Advancement of Clinical Gene Transfer and Therapy
20062011, LSHB-CT-2006-018933, funded by the EU

VITROCELLOMICS - Reducing Animal Experimentation in Preclinical Predictive Drug Testing by Human Hepatic in vitro Models Derived from Embryonic Stem Cells
20062009, funded by EU (LSHB-CT-2006-018940)

BACULOGENES – Baculovirus Vectors for Gene Therapy
20062009, FP6 - 2007, funded by the EU

MARKVAC - Development of marker vaccines, companion diagnostic tests and improvement of epidemiological knowledge to facilitate control of rinderpest and peste des petits ruminants viruses
20052007, RP/PPR MARKVAC, funded by the EU

EPIGENEVAC - Epidemiology and new generation vaccines for Ehrlichia and Anaplasma infections of ruminants
20052009, FP6-003713-INCO-DEV-1, funded by the EU

CELLPROM - Cell Programming by Nanoscaled Devices
20042009, NMP4-CT-2004-500039, funded by the EU

INSERTAGENE - Integrated Strategies for efficient therapeutic retrovirus based on modular cell lines
20032005, QLK3-CT-2002-01949, funded by the EU

ROTASAFE - Novel strategies for a safe rotavirus vaccine
20032005, QLRT-2001-01249, funded by the EU

COWDRIA - Mass production of Cowdria ruminantium to produce a cost effective veterinary vaccine against heartwater
20012004, 8-ACP-TPS-040, funded by the EU

ORALVAC - Development of Oral Vaccines, Role of Wildlife in The Maintenance of these Diseases
20012004, ICA4-CT-2000-30027, funded by the EU

Concluded projects (National Funding)

Molecular approaches to develop an insect cell production system for Hepatitis C vaccine candidate
20142015, EXPL/BBB-BIO/1129/2013, funded by FCT, Portugal

Establishment of a flexible insect cell platform for fast production of pseudo-typed VLPs for drug and vaccine development
20142015, EXPL/BBB-BIO/1541/2013, funded by FCT, Portugal

Development of a scalable strategy for stem cells purification
20132014, EXPL/BBB-EBI/1003/2012, funded by FCT, Portugal.

Systems biotechnology for improved production of biopharmaceuticals in animal cells
20132015, PTDC/BBB-BSS/0518/2012, funded by FCT, Portugal.

Combining siRNA and AAV therapy approaches to target human basal-like breast cancer: from vector development to anti-tumor efficacy evaluation
20132015, PTDC/BBB-BIO/1240/2012, funded by FCT, Portugal.

Integrative approaches to depict human cardiac stem cell receptome and its role in the cardiac regenerative process
20132015, PTDC/BBB-BIO/1414/2012, funded by FCT, Portugal.

Development of function blocking antibodies using Phage Display Technology: Inhibiton of the Notch1 signaling pathway by function blocking anti-jagged 1 antibody
20122015, PTDC/SAU-ONC/121670/2010, funded by FCT, Portugal

A novel generation of packaging cell lines for the manufacture of lentivirus based biopharmaceuticals
20122015, PTDC/EBB-BIO/118615/2010, funded by FCT, Portugal.

Development of improved suspension MDCK cell lines for the production of viral based bioproducts: manufacturing Influenza and Adenovirus
20122015, PTDC/EBB-EBI/118621/2010, funded by FCT, Portugal.

Human central nervous system in vitro models for preclinical research: new tools for studying viral vector-mediated gene
20122015, PTDC/EBB-BIO/119243/2010, funded by FCT, Portugal.

Probing adenovirus-host cell interactions: a systems biotechnology approach to improve production of gene delivery vectors
20122015, PTDC/EBB-BIO/119501/2010, funded by FCT, Portugal.

3D in vitro models for reducing animal experimentation in pharmaceutical development: integrative approaches for prediction of hepatic drug metabolism and neurotoxicity
20112014, PTDC/EBB-BIO/112786/2009, funded by FCT, Portugal.

2D fluorometry: a powerful tool to improve mammalian cell process development
20102012, PTDC/EBB-EBI/102750/2008, funded by FCT, Portugal.

Novel Cell Factories for the production of secreted complex bioproducts: a syntetic biology approach for improved product Stoichiometries
20102012, PTDC/EBB-EBI/102266/2008, funded by FCT, Portugal.

BACULOME-Engineering cellular energetics for improvement of bioprocesses: metabolic modeling for enhanced vaccines production
20102012, PTDC/EBB-EBI/103359/2008, funded by FCT, Portugal.

Retroviral like particles: improving potential as candidate vaccines for Hepatitis C
20102012, PTDC/EBB-BIO/102649/2008, funded by FCT, Portugal.

Using functional genomics to improve mammalian cells for virus based biopharmaceuticals manufacture
20102012, PTDC/EBB-BIO/100491/2008, funded by FCT, Portugal.

Preconditioning triggered by Carbon monoxide: new strategies to prevent brain damage due to hypoxia-ischemia and reperfusion
20102012, PTDC/SAU-NEU/098747/2008, funded by FCT, Portugal.

Integrated strategies for expansion, neuronal differentiation and cryopreservation of human embryonic stem cells
20092012, funded by FCT (PTDC/BIO/72755/2006)

Fundamentals of downstream processing of enveloped viruses: towards an integration of purification processes
20072010, funded by FCT (PTDC/EQU-EQU/71645/2006)

Manufacturing canine adenovirus vectors for gene therapy: development of MDCK CAV-2E1- transcomplementing cell lines
20072010, funded by FCT (PTDC/BIO/69452/2006)

Development of flexible cell lines for the Production of Retrovirus and Lentivirus for Gene Therapy
20072010, funded by FCT (PTDC/BIO/69451/2006)

Novel stroke model for neuroprotective research: bioreaction of primary brain cell aggregates
20072010, funded by FCT (PTDC/BIO/69407/2006)

Carbon monoxide as a neuroprotective agent against hypoxia-ischemia and reperfusion
20072010, funded by FCT, Portugal (PTDC/SAU-NEU/64327/2006)

Advanced Control of BHK Cultivation Processes Based on Intracellular Metabolic Fluxes
20052007, funded by FCT, Portugal (POCI/BIO/57927/2004)

THERAVECT - Production, Purification and Storage of Retroviral Vectors Produced by Modular Master Producer Cells
20052007, funded by FCT, Portugal (010.6/A003/2005)

CELL CRYOTHERA - Cell Cryopreservation for Therapy and Regenerative Medicine
20052007, funded by FCT, Portugal (010.6/A006/2005)

Genetics, Stoicheometry and Kinetics of Multiple Protein Assembly: the case for a Rotavirus Like Particle
20052007, funded by FCT (POCTI/BIO/55975/2004)

Integrated strategy for the production, purification and storage of adenovirus
20042006, funded by FCT, Portugal (POCTI/BIO/46515/2002)

Metabolic Trafficking between neurons and astrocytes under stress conditions implicated in neurological disorders
20032006, funded by FCT, Portugal (POCTI/BIO/39214/2001)

Cell cycle control for better biotechnological methods in therapeutic protein production
20012003, funded by FCT, Portugal (POCTI/BIO/35687/2000)

Stabilization of retroviruses for gene therapy clinical applications
20012003, funded by FCT, Portugal (POCTI/BIO/35695/2000)