Proteins for Structure Function Research

Determination of protein structural characteristics is becoming increasingly used for drug design. Target protein production with the required purity for structural studies is one of our areas of expertise. Over the last years we have produced several nuclear receptors binding domains and kinases for structural studies.

For evaluation of the interaction between the target protein and candidate drugs, protein co-purification with inhibitors, ligands, agonists and antagonists are routinely performed.

For these processes the main expression systems used are E.Coli and Insect Cells / Baculovirus systems.

For structural studies, IBET has strong competencies 3D-structural elucidation of macromolecules by crystallography and NMR. IBET has available in-house X-ray and NMR facilities.