The poster Development of antibodies against the Notch ligand Delta-Like-1 with activity against ER+ breast cancer received the “Best Poster Award” for the “Cancer Biomarkers and New Therapies” category in the webinar Cancer Biology: from Basic to Translational Research, organized by Liga Portuguesa contra o Cancro (Portuguese Cancer League).
The awarded research project is a collaborative effort between iBET, ITQB-NOVA, Nova Medical School, FCT-NOVA and Hospital de São José, and describes the development of antibodies targetting Notch ligand Delta-Like-1 (DLL1) as candidates for breast cancer therapy.
DLL1 was recently associated with estrogen receptor-positive (ER+) subtypes of breast cancer with poor prognosis thus, revealing itself as a promising new therapeutic target. The antibody developed in this research significantly inhibited tumor growth in ER+ breast cancer mice model stressing DLL1 targetting immunotherapies as promissing therapeutic strategies.
Authors of the awarded work: Gabriela Silva, Joana Sales-Dias, Diogo Casal, Sara Alves, Andreia Ferreira, Giacomo Domenici, Ana R. Lemos, Khrystyna Kucheryava, Pedro M. F. Sousa, Tiago M. Bandeiras, Paula Videira and Ana Barbas.
“Cancer Biology: From Basic To Translational Research” aimed to bring together researchers in basic and clinical oncology to present the most promising results that might have a clinical impact in the oncology field. Different thematics of tumor complexity were addressed, e.g. genetics, biomarkers, tumor microenvironment, tumor metabolism, and new potential therapeutic targets.