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October 16, 2020

The poster Development of antibodies against the Notch ligand Delta-Like-1 with activity against ER+ breast cancer received the “Best Poster Award” for the “Cancer Biomarkers and New  Therapies” category in the webinar Cancer Biology: from Basic to Translational Research, organized by Liga Portuguesa contra o Cancro (Portuguese Cancer League).

The awarded research project is a collaborative effort between iBET, ITQB-NOVA, Nova Medical School, FCT-NOVA and Hospital de São José, and describes the development of antibodies targetting Notch ligand Delta-Like-1 (DLL1) as candidates for breast cancer therapy.

DLL1 was recently associated with estrogen receptor-positive (ER+) subtypes of breast cancer with poor prognosis thus, revealing itself as a promising new therapeutic target. The antibody developed in this research significantly inhibited tumor growth in ER+ breast cancer mice model stressing DLL1 targetting immunotherapies as promissing therapeutic strategies.

Authors of the awarded work: Gabriela Silva, Joana Sales-Dias, Diogo Casal, Sara Alves, Andreia Ferreira, Giacomo Domenici, Ana R. Lemos, Khrystyna Kucheryava, Pedro M. F. Sousa, Tiago M. Bandeiras, Paula Videira and Ana Barbas.

Best Poster Award Certificate at “Cancer Biology: From Basic to Translational Research” Webinar

“Cancer Biology: From Basic To Translational Research” aimed to bring together researchers in basic and clinical oncology to present the most promising results that might have a clinical impact in the oncology field. Different thematics of tumor complexity were addressed, e.g. genetics, biomarkers, tumor microenvironment, tumor metabolism, and new potential therapeutic targets.

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