Our research combines the use of experimental and theoretical engineering approaches in the development of new advanced purification materials, processes and novel analytical tools for bioseparation applications. Our goal is to setup scalable, highly efficient and cost effective downstream processes for complex biopharmaceuticals including cell-based products, aiming technology transfer for manufacturing. In addition to this, our research activities focus on the integrated and continuous processes, mainly continuous counter-current chromatography for exosomes, viral vaccines and gene therapy vectors. The use of mathematical models allows a rational design of downstream processing steps together and the identification of critical process parameters enabling optimal purification and global recovery yield.
