Research Fellowship (PhD) – Translational Immunology

iBET, has an open position for a research fellowship in the field of Translational Immunology available within the project “Translational Immunology” Ref. 047, financed by internal funds.

PhD Degree in Biological, Chemical or Biomedical Engineering, Biotechnology, Biology, Biochemistry, Immunology, or relevant scientific field with knowledge in Molecular Biology, In vitro Cellular Models, Immunology, Immuno-Oncology or equivalent.

The successful candidate will complement existing knowledge in the team with Immunology, cellular engineering and molecular biology competences. A strong candidate will have in-depth experience in mammalian cell genetic engineering and molecular biology tools as well as good knowledge of cellular immunology.

Technical Skills

• Highly autonomous and productive in performing laboratory research or method development
• Good understanding of the interplay between adaptive/innate immunology with relevance to prevention and therapy of diseases.
• Experience in cell culture of primary immune cells and mammalian cell lines
• Experience in molecular biology and genetic engineering methods (including PCR, transcriptomics, vector cloning, cell transfection and lentivirus transduction, targeted/site-specific integration)
• Experience in cell analytic methods (flow cytometry, fluorescent microscopy, functional assays)
• Experience in relevant software for data analysis and visualization (e.g. GraphPad Prism, ImageJ, FlowJo, R)
• Experience of interacting optimally across subject areas, cultures and expertise
• Experience in collaboration projects with both academic and pharmaceutical industry partners
• Proficiency in English, spoken and written

Soft Skills

• Strong motivation to work in a fast-paced, collaborative environment with strong focus on applied research.
• Curiosity, flexible mindset and willingness to learn
• Good communication and organization skills
• Motivation to work as a team player as well as individually
• Initiative and creativity to generate new scientific ideas in research or development activities.
• Good communication and organization skills
• International research experience
• Experience in supervision

• Culture primary immune cells, cell lines and human induced Pluripotent Stem Cells (hiPSCs), modify them genetically and analyze their functionality through molecular and functional assays.
• Establish analytical methods for characterization of immune cell function, namely Macrophages, Natural killer, Dendritic and T cells.
• Generate and validate cell-based platforms for tumor-specific antigen display by assessing its ability to induce antibody mediated responses and trigger the tumoricidal potential of immune cells.
• Develop in vitro functional assays to evaluate the potency of modified immune cells carrying Chimeric Antigen Receptor (CAR) constructs.
• Establish protocols for differentiation of lymphoid cell populations from hiPSCs.
• Mentorship of MSc, PhD students
• Effectively collaborate and communicate with colleagues in multidisciplinary projects.

The fellowship will have a duration of 12 months, eventually renewed until the end of project, without prejudice of the maximum limits foreseen by law. The expected starting date is 15 of May of 2025.

Apply now with your detailed CV, motivation letter, and diploma certificates to jobs@ibet.pt, referring to the job reference in the subject of the email “BPD_ 047 Translational Immunology”.