MECHANISMS OF HAEMATOPOIETIC STEM CELL SURVIVAL AND DIFFERENTIATION REVEALED BY A ZEBRAFISH MODEL OF GATA2 DEFICIENCY
Host: Catarina Brito
Biosketch: Dr Rui Monteiro is a Birmingham Fellow and Principal Investigator at the Institute of Cancer and Genomic Sciences, University of Birmingham, UK since 2018. Rui earned his PhD in Developmental Biology in Prof Christine Mummery’s lab at the Hubrecht Institute (2005) and did his postdoctoral training in developmental haematopoiesis at the Weatherall Institute, University of Oxford with Prof Roger Patient. In 2014, he was awarded a BHF Intermediate Fellowship to study TGFbeta signalling in HSC emergence. More recently, his lab has generated an enhancer deletion mutant that models key aspects of GATA2 deficiency in humans (Dobrzycki et al, 2020, Comm Biol). The Monteiro Lab studies the fundamental mechanisms underpinning haematopoiesis in development and homeostasis and how perturbations in these mechanisms lead to haematopoietic disease.