Researchers from Stem Cell Bioengineering Lab were present at the First Meeting of The Portuguese Network of Extracellular Vesicles (PNEV) , held in Porto from 13 to 14 September 2021.
Ana Filipa Louro presented an oral communication entitled “Temporal profiling of extracellular vesicle (EV) miRNome in hiPSC-cardiomyocyte differentiation for the identification of cell biofactories for therapeutic EV production”, selected for the session “EVs in tissue regeneration and degeneration”. The research work aims to elucidate the role of bioactive microRNA content present in EV secreted during hiPSC-cardiomyocyte differentiation. The goals are to identify and select suitable cell biofactories for EV production, and to identify genetic signatures of therapeutically relevant EV.
In addition to Ana Filipa’s oral communication, iBET contributed with two short talks focused on regenerative properties of EV:
- Scalable and chemically-defined manufacturing of mesenchymal stromal cells-derived extracellular vesicles with augmented cardiac regenerative properties (presenting author: Margarida Costa)
- Empowering the therapeutic potential of clinically expired platelet concentrates: a new source of regenerative EV (presenting author: Ana Meliciano)
Extracellular Vesicles are currently the focus of several studies as promising therapeutic tools, for example, cell transplantation in the context of heart failure. The first meeting of the Portuguese Network on Extracellular Vesicles (PNEV), brought together researchers and students working in the field of EVs in Health and Disease, highlighting outstanding research on EVs in Portugal.