Downstream Process Development Lab
Ground-breaking technologies for purification of new modalities
Research Focus
The Downstream Process Development lab scientific research activities are anchored in applied technology where we are committed to providing innovative purification trains for novel biotherapeutics.
Our latest work has focused on the development of alternative processes using advanced materials and faster purification workflows when compared to traditional chromatographic methods.
Areas of Activity
Downstream process intensification
Implementation of solutions for reducing the purification time of labile viruses, coupling harvest steps with clarification and capture using scale-down models. Evaluation of periodic counter current and rapid cycling chromatography for enveloped viruses.
Purification Process understanding
Development and implementation of (near) real time process monitoring and control with label-free technologies (based on biolayer interferometry, mass photometry and HPLC) for different viral vectors, replacing the traditional and less efficient methodologies.
Advanced purification materials and new biological targets
Scalability of precisely patterned purification nanofibers as alternatives for capture aiming to reduce environmental footprint and increase productivity. Production and purification process development of different enveloped viruses.
Cristina Peixoto
Head of Downstream Process Development lab, Coordinator of Bioproduction Unit
I have been the Head of the Downstream Process Development lab of iBET since 2009 and also currently coordinate the Bioproduction Unit. I have managed more than 50 research contract projects with industrial partners, some of the processes developed are now at the clinical stage.
