We are focused on research and development of complex biopharmaceuticals namely for the production, purification and storage of vaccines (e.g. virus like particles-VLP’s and marker vaccines), recombinant proteins (e.g. MAbs) and viral vectors (adenovirus, retrovirus, lentivirus and baculovirus). In particular we aim at understanding cell physiology and metabolism to improve the efficiency of bioprocesses.
We are also interested in the development of methodologies for pre-clinical research and cell therapy applications, namely in 3D cell models, bioreactor technology and novel cell cryopreservation strategies. Current efforts are on novel 3D in vitro models of infection and for hepato- and cardio-toxicology, employing human stem cells and primary cultures of human hepatocytes.