We are focused on designing improved bioprocesses for vaccines manufacturing. The basis of our research lies on the use and integration of multidisciplinary technologies such as molecular biology, bioprocess and evolutionary engineering, and bottom-up systems biology for optimizing the cell factory (mammalian and insect), the expression system (transient and stable), the culture system, the bioreactor operation mode (perfusion and continuous) or the scale-up process. To complement upstream activities, our team dedicates time to devising innovative solutions for increasing product recovery yields and quality, and assays for product characterization and purity assessment. The aim is to gain development efficiencies that speed the manufacturing process of vaccines (e.g. virus-like particles).