iBET at Biomanufacturing Without Borders Conference in Lisbon

Best Oral Presentation: Advancing CAR-T Cell Manufacturing Through Tight Control of Cell Activation in STBs

Researchers from iBET’s Stem and Immune Cells Bioengineering Lab actively participated in the Biomanufacturing Without Borders (BWB) Conference, held in Lisbon on November 28-29.

The event gathered experts from various disciplines to discuss the latest innovations in bioprocessing. Key topics included cell-based therapies (such as stem cells and extracellular vesicles), biomaterials for therapeutic applications, 3D models for drug screening, and bioprocess optimization (including scale-up, AI, and big data).

BWB2024, supported by the Institute for Bioengineering and Biosciences (IBB), Instituto Superior Técnico de Lisboa, and the Portuguese Society for Stem Cells and Cell Therapies (SPEC-TC), featured significant contributions from iBET’s scientists.

Invited and Selected Oral Presentations

Margarida Serra, Head of the Stem and Immune Cells Bioengineering Lab and Invited Speaker, delivered a presentation on “Nature-inspired Bioprocesses to Advanced Cell Therapy Manufacturing”.

Top: Margarida Serra, Bottom: Claúdia Diniz.

In addition, Cláudia Diniz and Margarida Costa, PhD students from the same lab, delivered oral presentations on Bioengineering of hiPSC-cardiac derivatives for the development of a personalized regenerative biological ventricular assist device and “Advancing CAR-T cell manufacturing through tight control of cell activation in stirred-tank bioreactors”, respectively.

Special congratulations to Margarida Costa, who earned the Best Oral Presentation award at the event!

Margarida Costa receiving the award and delivering her presentation

Flash Talks: Manufacturing CAR-T cells & Optimization of hWJ-MSC Colonization

Constança Costa presented a flash talk on “Manufacturing CAR-T cells with increased clinical relevancy through enhanced process control in stirred-tank bioreactors”.

Victor Garcia-Gragera, visiting PhD student from Instituto Químico de Sarrià (Barcelona), contributed with a flash talk on “Optimized hWJ-MSC Colonization in microcarrier-based Stirred Tank Bioreactors using Design of Experiments”.

Posters: Biomanufacturing of EVs from Immature Cardiomyocytes & Scalable Bioprocess Optimization for γδ T cells

João Jacinto and Miguel Fuzeta, presented two poster communications on “Biomanufacturing of immature cardiomyocytes derived extracellular vesicles in 2L stirred tank bioreactor” and “Scalable and Chemically-Defined Differentiation Bioprocess to Generate γδ T Cells from Hematopoietic Stem/Progenitor Cells”.

From left to right: Victor Garcia-Gragera (visiting PhD student), João Jacinto, Constança Costa, Margarida Costa, Claúdia Diniz and Miguel Fuzeta.

The active participation and accomplishments of iBET researchers at BWB2024 reflect the institution’s dedication to driving innovation in cell-based therapies, bioprocess optimization, and regenerative medicine.

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