iBET’s Bioanalytics Expertise with 2 Oral Presentations at Protein & Antibody Engineering Summit 2024
Streamlining CHO Clone Characterization Workflows & Characterization of mAbs Attributes by Advanced MS-based Bioanalytics
A team of iBET scientists participated in the 16th Annual Protein and Antibody Engineering Summit (PEGS) Europe, held in Barcelona, Spain, from November 5-7.
The event brought together over 1,500 experts to discuss key advancements in the field, with this year’s program emphasizing AI/machine learning, multispecific antibodies (MsAbs), antibody-drug conjugates, and oncology innovations.
iBET contributed to the scientific program with two impactful oral presentations:
“Streamlining CHO Clone Characterisation Workflows: Omics Signatures of Multispecific Antibodies Mispairing”
Patrícia Alves addressed a key challenge in MsAbs production, the incorrect chain assembly and co-production of mispaired species which can compromise biological activity.
She also highlighted iBET’s work on the application of omics analyses for the characterization of CHO clones producing trispecific antibodies, and how it could help streamlining the selection of hosts with improved MsAb quality, reducing development and manufacturing process time and costs.
“Characterisation of mAbs Attributes and HCP Clearance by Advanced Mass Spectrometry-Based Bioanalytics”
Sofia Carvalho discussed the use of a MS-based Multiple Attribute Method (MAM) to assess post-translational modifications (PTMs) in CHO-derived mAbs and a SWATH-MS method to identify and quantify high-risk HCPs.
These bioanalytical tools were developed to characterize a DSP polishing platform, enabling the identification of the best design space, maximizing product quality and purification performance.
In addition to these presentations, iBET scientists Daniel Simão, Joana Dias, and Rute Eleutério also attended the conference.
Daniel Simão, Sofia Carvalho, Joana Dias, Rute Eleutério, Patrícia Alves
These contributions underscored iBET’s competences in bioanalytics and bioprocessing optimization, reaffirming its relevant role in advancing the development and manufacturing of biopharmaceuticals.