Publications

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Advanced Technologies for Gene Therapy Products
Dielectric Spectroscopy to Improve the Production of rAAV Used in Gene Therapy
Processes
Pais DAM, Brown C, Neuman A, Mathur K, Isidro IA, Alves PM, Slade PG
2020
Bioengineering for Cell-based Therapies
Unveiling dynamic metabolic signatures in human induced pluripotent and neural stem cells
PLOS Computational Biology
Vasconcelos JS, Simão D, Terrasso AP, Silva MM, Brito C, Isidro IA, Alves PM, Carrondo MJT
2020
Advanced Cell Models for Drug Discovery and Translational Research
Development of Novel Galactosylated PLGA Nanoparticles for Hepatocyte Targeting Using Molecular Modelling
Polymers
Raposo CD, Costa R, Petrova KT, Brito C, Scotti MT, Cardoso MM
2020
Advanced Cell Models for Drug Discovery and Translational Research
Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis
Cells
Lopes-Coelho F, Silva F, Gouveia-Fernandes S, Martins C, Lopes N, Domingues G, Brito C, Almeida AM, Pereira SA, Serpa J
2020
Vaccines Bioprocess Engineering
Improving Influenza HA-Vlps Production in Insect High Five Cells via Adaptive Laboratory Evolution
Vaccines
Correia R, Fernandes B, Alves PM, Carrondo MJT, Roldao A
2020
Advanced Technologies for Gene Therapy Products
Baculovirus affinity removal in viral-based bioprocesses
Separation and Purification Technology
Moleirinho MG, Fernandes RP, Carvalho SB, Bezemer S, Detmers F, Hermans P, Silva RJS, Alves PM, Carrondo MJT, Peixoto C
2020
Advanced Technologies for Gene Therapy Products
3D-printed ordered bed structures for chromatographic purification of enveloped and non-enveloped viral particles
Separation and Purification Technology
Moleirinho MG, Feast S, Moreira AS, Silva RJS, Alves PM, Carrondo MJT, Huber T, Fee C, Peixoto C
2020
Advanced Technologies for Gene Therapy Products
Advances in lentivirus purification
Biotechnology Journal
Moreira AS, Cavaco D, Faria T, Alves PM, Carrondo MJT, Peixoto C
2020
Advanced Cell Models for Drug Discovery and Translational Research
A computational diffusion model to study antibody transport within reconstructed tumor microenvironments
BMC Bioinformatics
Cartaxo AL, Almeida J, Gualda EJ, Marsal M, Loza-Alvarez P, Brito C, Isidro IA
2020
Bioengineering for Cell-based Therapies
Towards a microencapsulated 3D hiPSC-derived in vitro cardiac microtissue for recapitulation of human heart microenvironment features
Frontiers in Bioengineering and Biotechnology
Abecasis B, Canhão PGM, Almeida HV, Calmeiro T, Fortunato E, Gomes-Alves P, Serra M, Alves PM
2020
Enabling PAT in insect cell bioprocesses: In situ monitoring of recombinant adeno‐associated virus production by fluorescence spectroscopy
Biotechnology and Bioengineering
Pais DAM, Portela RMC, Carrondo MJT, Isidro IA, Alves PM
2019
Vaccines Bioprocess Engineering
Efficient filtration strategies for the clarification of influenza virus-like particles derived from insect cells
Separation and Purification Technology
Carvalho SB, Silva RJS, Moreira AS, Cunha B, Clemente JJ, Alves PM, Carrondo MJT, Xenopoulos A, Peixoto C
2019
Bioengineering for Cell-based Therapies
Pluripotent stem cells for drug development and therapy: bioprocess development challenges
Annals of Medicine
Alves PM
2019
Advanced Technologies for Gene Therapy Products
Exosome-based therapeutics: Purification using semi-continuous multi-column chromatography
Separation and Purification Technology
Moleirinho MG, Silva RJS, Carrondo MJT, Alves PM, Peixoto C
2019
Advanced Technologies for Gene Therapy Products
Detection and Quantification of Label-Free Infectious Adenovirus Using a Switch-On Cell-Based Fluorescent Biosensor
ACS Sensors
Guerreiro MR, Freitas DF, Alves PM, Coroadinha AS
2019
Vaccines Bioprocess Engineering
Process intensification for Peste des Petites Ruminants Virus vaccine production
 Vaccine
Sousa M, Fenge C, Rupprecht J, Tappe A, Greller G, Alves P, Carrondo M, Roldão A
2019
Bioengineering for Cell-based Therapies
Unveiling the molecular crosstalk in a human induced pluripotent stem cell‐derived cardiac model
Biotechnology and Bioengineering
Abecasis B, Gomes‐Alves P, Rosa S, Gouveia PJ, Ferreira L, Serra M, Alves PM
2019
Advanced Technologies for Gene Therapy Products
Current challenges in biotherapeutic particles manufacturing
Expert Opinion on Biological Therapy
Moleirinho MG, Silva RJS, Alves PM, Carrondo MJT, Peixoto C
2019
Advanced Technologies for Gene Therapy Products
Enhancing Hepatitis C virus pseudoparticles infectivity through p7NS2 cellular expression
Journal of Virological Methods
Soares HR, Ferreira-Fernandes M, Marchel M, Alves PM, Coroadinha AS
2019
Advanced Technologies for Gene Therapy Products
Evaluation of AAV-mediated delivery of shRNA to target basal-like breast cancer genetic vulnerabilities
Journal of Biotechnology
Pinto C, Silva G, Ribeiro AS, Oliveira M, Garrido M, Bandeira VS, Nascimento A, Coroadinha AS, Peixoto C, Barbas A, Paredes J, Brito C, Alves PM
2019
Advanced Technologies for Gene Therapy Products
Improved GaLV-TR Glycoproteins to Pseudotype Lentiviral Vectors: Impact of Viral Protease Activity in the Production of LV Pseudotypes
Molecular Therapy - Methods & Clinical Development
H A Tomás, D A Mestre, A F Rodrigues, M R Guerreiro, M J T Carrondo, A S Coroadinha
2019
Advanced Cell Models for Drug Discovery and Translational Research
Flexible 3D Cell-Based Platforms for the Discovery and Profiling of Novel Drugs Targeting Plasmodium Hepatic Infection
ACS Infectious Diseases
Arez F, Rebelo SP, Fontinha D, Simão D, Martins TR, Machado M, Fischli C, Oeuvray C, Badolo L, Carrondo MJT, Rottmann M, Spangenberg T, Brito C, Greco B, Prudêncio M, Alves PM
2019
Natural Bioactives & Nutraceuticals
Polymethoxylated Flavones Target Cancer Stemness and improve the Antiproliferative Effect of 5-Fluorouracil in a 3D Cell Model of Colorectal Cancer
Nutrients
C V Pereira, M Duarte, P Silva, A Bento da Silva, C M M Duarte, A Cifuentes, V García-Cañas, M R Bronze, C Albuquerque, A T Serra
2019
Bioengineering for Cell-based Therapies
Definition of a cell surface signature for human cardiac progenitor cells after comprehensive comparative transcriptomic and proteomic characterization
Scientific Reports
Torán JL, López JA, Gomes-Alves P, Aguilar S, Torroja C, Trevisan-Herraz M, Moscoso I, Sebastião MJ, Serra M, Brito C, Cruz FM, Sepúlveda JC, Abad JL, Galán-Arriola C, Ibanez B, Martínez F, Fernández ME, Fernández-Aviles F, Palacios I, R-Borlado L, Vázquez J, Alves PM, Bernad A
2019