Publications

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Bioengineering for Cell-based Therapies
Pluripotent stem cells for drug development and therapy: bioprocess development challenges
Annals of Medicine
Alves PM
2019
Advanced Technologies for Gene Therapy Products
Exosome-based therapeutics: Purification using semi-continuous multi-column chromatography
Separation and Purification Technology
Moleirinho MG, Silva RJS, Carrondo MJT, Alves PM, Peixoto C
2019
Advanced Technologies for Gene Therapy Products
Detection and Quantification of Label-Free Infectious Adenovirus Using a Switch-On Cell-Based Fluorescent Biosensor
ACS Sensors
Guerreiro MR, Freitas DF, Alves PM, Coroadinha AS
2019
Vaccines Bioprocess Engineering
Combining stable insect cell lines with baculovirus-mediated expression for multi-HA influenza VLP production
Vaccine
Sequeira DP, Correia R, Carrondo MJT, Roldão A, Teixeira AP, Alves PM
2018
Bioengineering for Cell-based Therapies
3D aggregate culture improves metabolic maturation of human pluripotent stem cell derived cardiomyocytes
Biotechnology and Bioengineering
Correia C, Koshkin A, Duarte P, Hu D, Carido M, Sebastião MJ, Gomes-Alves P, Elliott DA, Domian I, Teixeira AP, Alves PM, Serra M
2018
Protein Biophysics for Drug Discovery
The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones
Nature Communications
C Maurizy, M Quinternet, Y Abel, C Verheggen, PE Santo, M Bourguet, ACF Paiva, B Bragantini, M Chagot, M Robert, C Abeza, P Fabre, P Fort, F Vandermoere, PMF Sousa, JC Rain, B Charpentier, S Cianférani, TM Bandeiras, B Pradet-Balade, X Manival, E Bertrand
2018
Vaccines Bioprocess Engineering
Synthetic biology for bioengineering virus‐like particle vaccines
Biotechnology and Bioengineering
Charlton Hume HK, Vidigal J, Carrondo MJT, Middelberg APJ, Roldão A, Lua LHL
2018
Advanced Technologies for Gene Therapy Products
LentiPro26: novel stable cell lines for constitutive lentiviral vector production.
Natura Scientific Reports
HA Tomás, A F Rodrigues, M J T Carrondo MJT, A S Coroadinha
2018
Advanced Cell Models for Drug Discovery and Translational Research
Recapitulation of Human Neural Microenvironment Signatures in iPSC-Derived NPC 3D Differentiation.
Stem Cell Reports
Simão D, Silva MM, Terrasso AP, Arez F, Sousa MFQ, Mehrjardi NZ, Šarić T, Gomes-Alves P, Raimundo N, Alves PM, Brito C
2018
Advanced Cell Models for Drug Discovery and Translational Research
Recapitulation of Human Neural Microenvironment Signatures in iPSC-Derived NPC 3D Differentiation
Stem Cell Reports
Simão D, Silva MM, Terrasso AP, Arez F, Sousa MFQ, Mehrjardi NZ, Šarić T, Gomes‑Alves P, Raimundo N, Alves PM, Brito C
2018
Bioengineering for Cell-based Therapies
Expansion of 3D human induced pluripotent stem cell aggregates in bioreactors: Bioprocess intensification and scaling-up approaches
Journal of Biotechnology
Abecasis B, Aguiar T, Arnault É, Costa R, Gomes‑Alves P, Aspegren A, Serra M, Alves PM
2017
Bioengineering for Cell-based Therapies
Distinct carbon sources affect structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells
Nature Scientific Reports
Correia C, Koshkin A, Duarte P, Hu DJ, Teixeira AP, Domian IJ, Serra M. and Alves PM*
2017
In vitro expansion of human cardiac progenitor cells: exploring ’omics tools for characterization of cell-based allogeneic products
Translational Research
Gomes-Alves, P. and Serra, M. and Brito, C. and Ricardo, C.P. and Cunha, R. and Sousa, M.F. and Sanchez, B. and Bernad, A. and Carrondo, M.J.T. and Rodriguez-Borlado, L. and Alves, P.M.
2016
Bioengineering for Cell-based Therapies
Stem Cell-Derived Systems in Toxicology Assessment
Stem Cells and Development
Suter-Dick, L.; Alves, P. M.; Blaauboer, B. J.; Bremm, K.-D.; Brito, C.; Coecke, S.; Flick, B.; Fowler, P.; Hescheler, J.; Ingelman-Sundberg, M.; Jennings, P.; Kelm, J. M.; Manou, I.; Mistry, P.; Moretto, A.; Roth, A.; Stedman, D.; van de Water, B.; Beilmann, M.
2015
Bioengineering for Cell-based Therapies
Exploring continuous and integrated strategies for the up- and downstream processing of human mesenchymal stem cells
Journal of Biotechnology
Cunha B, Aguiar T, Silva MM, Silva RJS, Sousa MFQ, Pineda E, Peixoto C, Carrondo MJT, Serra M, Alves PM
2015
Natural Bioactives & Nutraceuticals
Production of a natural red pigment derived from Opuntia spp. using a novel high pressure CO2assisted-process
RSC Advances
Nunes, A. N.; Saldanha do Carmo, C.; Duarte, C. M. M.
2015
Bioengineering for Cell-based Therapies
Robust Expansion of Human Pluripotent Stem Cells: Integration of Bioprocess Design With Transcriptomic and Metabolomic Characterization
Stem Cells Translational Medicine
Silva, M. M.; Rodrigues, A. F.; Correia, C.; Sousa, M. F. Q.; Brito, C.; Coroadinha, A. S.; Serra, M.; Alves, P. M.
2015
Natural Bioactives & Nutraceuticals
Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study
American Journal of Clinical Nutrition
S Silva, M R Bronze, M E Figueira, J Siwy, H Mischak, E Combet, W Mullen
2015
Bioengineering for Cell-based Therapies
Production of oncolytic adenovirus and human mesenchymal stem cells in a single‐use, Vertical‐Wheel bioreactor system: Impact of bioreactor design on performance of microcarrier‐based cell culture processes
Biotechnology Progress
Sousa, M. F. Q.; Silva, M. M.; Giroux, D.; Hashimura, Y.; Wesselschmidt, R.; Lee, B.; Roldão, A.; Carrondo, M. J. T.; Alves, P. M.; Serra, M.
2015
Bioengineering for Cell-based Therapies
Three-dimensional co-culture of human hepatocytes and mesenchymal stem cells: improved functionality in long-term bioreactor cultures: 3D co-cultures of human hepatocytes and MSCs in bioreactors
Journal of Tissue Engineering and Regenerative Medicine
Rebelo, S. P.; Costa, R.; Silva, M. M.; Marcelino, P.; Brito, C.; Alves, P. M.
2015
Bioengineering for Cell-based Therapies
Exploring analytical proteomics platforms toward the definition of human cardiac stem cells receptome
Proteomics
Gomes-Alves, P.; Serra, M.; Brito, C.; R.-Borlado, L.; López, J. A.; Vázquez, J.; Carrondo, M. J. T.; Bernad, A.; Alves, P. M.
2015
Protein Biophysics for Drug Discovery
Microdosing of a Carbon‐14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages
Clinical Pharmacology & Therapeutics
Vlaming, M. L. H.; van Duijn, E.; Dillingh, M. R.; Brands, R.; Windhorst, A. D.; Hendrikse, N. H.; Bosgra, S.; Burggraaf, J.; de Koning, M. C.; Fidder, A.; Mocking, J. A. J.; Sandman, H.; de Ligt, R. A. F.; Fabriek, B. O.; Pasman, W. J.; Seinen, W.; Alves, T.; Carrondo, M.; Peixoto, C.; Peeters, P. A. M.; Vaes, W. H. J.
2015
Advanced Cell Models for Drug Discovery and Translational Research
Modeling Human Neural FunctionalityIn Vitro: Three-Dimensional Culture for Dopaminergic Differentiation
Tissue Engineering Part A
Simão, D.; Pinto, C.; Piersanti, S.; Weston, A.; Peddie, C. J.; Bastos, A. E. P.; Licursi, V.; Schwarz, S. C.; Collinson, L. M.; Salinas, S.; Serra, M.; Teixeira, A. P.; Saggio, I.; Lima, P. A.; Kremer, E. J.; Schiavo, G.; Brito, C.; Alves, P. M.
2015
Advanced Technologies for Gene Therapy Products
Bioactive transparent films based on polysaccharides and cholinium carboxylate ionic liquids
Green Chemistry
Tomé, L. C.; Silva, N. H. C. S.; Soares, H. R.; Coroadinha, A. S.; Sadocco, P.; Marrucho, I. M.; Freire, C. S. R.
2015