Publications

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Bioengineering for Cell-based Therapies
Billion‐Scale Expansion of Functional hiPSC‐Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation
Advanced Science
Vicente P, Inocêncio LR, Ullate‐Agote A, Louro AF, Jacinto J, Gamelas B, Iglesias‐García O, Martin‐Uriz PS, Aguirre‐Ruiz P, Ríos‐Muñoz GR, Fernández‐Santos ME, van Mil A, Sluijter JPG, Prósper F, Mazo MMV, Alves PM, Serra M
2025
Protein Biophysics for Drug Discovery
Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors
Journal of Medicinal Chemistry
Heinrich T, Gambardella A, Schwarz D, Petersson C, Gunera J, Garg S, Schneider R, Keil M, Grimmeisen L, Unzue Lopez A, Schilke H, Weitzel T, Kolb C, Diehl P, Doerfel B, Anlauf U, Reither V, Rettig C, Opelt B, Delp A, Wildner N, Musil D, Friedrich E, Burgdorf L, Fuchss T, Albers L, Sousa PMF, Freire F, Bandeiras TM, Wienke D.
2025
Advanced Cell Models for Drug Discovery and Translational Research
Sustained Macrophage Reprogramming Is Required for CD8+ T cell–Dependent Long-Term Tumor Eradication
Cancer Immunology Research
Jardim C, Bica M, Reis-Sobreiro M, Teixeira da Mota A, Lopes R, Pinto MF, Sousa NS, Mensurado S, Boekhoff H, Scolaro T, Reugebrink M, Goncalves-Sousa N, Kubo H, Gomes CM, Brito C, Argüello RJ, Leites EP, Morais VA, Silva-Santos B, Barbosa-Morais NL, Serre K
2025
Natural Bioactives & Nutraceuticals
Impact of low-moisture extrusion on carbohydrate constituents and antinutrients of a blend of a faba bean protein concentrate and a beta-glucan enriched oat fraction
Food Research International
Saldanha do Carmo C, Mecha E, Schmidt G, Oliveira J, Bronze MR, Knutsen SH, Serra AT
2025
Advanced Technologies for Gene Therapy Products
Deciphering key parameters enhancing lentiviral vector producer cells yields: Vector components copy number and expression
Molecular Therapy Methods & Clinical Development
Formas-Oliveira AS, Ferreira MV, Coroadinha AS
2025
Advanced Technologies for Gene Therapy Products
SLC20A1 knockout to stably express a fusogenic gibbon ape leukemia virus envelope glycoprotein for lentiviral vector production
Molecular Therapy Methods & Clinical Development
Nogueira RJ, Rodrigues AF, Mestre DA, Coroadinha AS
2025
Natural Bioactives & Nutraceuticals
Antibacterial and Antifungal Activity of Extracts from Five Portuguese Cowpea (Vigna unguiculata) Accessions
Molecules
Salamandane A, Candeias M, Lourenço S, Vieira EJF, Mecha E, Gomes R, Bronze R, Nunes C, Brito L
2025
Improving AAV8 purification with continuous affinity capture: From batch to continuous multicolumn chromatography
Journal of Biotechnology
Neto S, Rankine G, Bollmann F, Carrondo MJT, Silva RJS
2025
Protein Biophysics for Drug Discovery
An engineered cereblon optimized for high-throughput screening and molecular glue discovery
Cell Chemical Biology
Bailey HJ, Eisert J, Kazi R, Gerhartz J, Pieńkowska DE, Dressel I, Vollrath J, Kondratov I, Matviyuk T, Tolmachova N, Shah VJ, Giuliani G, Mosler T, Geiger TM, Esteves AM, Santos SP, Sousa RL, Bandeiras TM, Leibrock EM, Bauer U, Leuthner B, Langer JD, Wegener AA, Nowak RP, Sorrell FJ, Dikic I
2025
Advanced Cell Models for Drug Discovery and Translational Research
3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV
Scientific Reports
Ramella Gal I, Arez F, Correia IP, Domenici G, Fernandes S, Silva G, Saldanha I, Duarte N, Freitas C, Alves PM, Maier U, Coroadinha AS, du Plessis F, Brito C
2025
High-throughput flow cytometry-based titration of a live attenuated rotavirus vaccine
Journal of Biotechnology
Dias MM, Carvalho SB, Matheise JP, Van Beersel G, Knott I, Gomes-Alves P, Alves PM
2025
Advanced Cell Models for Drug Discovery and Translational Research
Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids
iScience
Gomes CM, Simão D, Gonçalves CC, Silva G, Painho B, Alves PM, Brito C
2025
Bioengineering for Cell-based Therapies
Heterotypic spheroids as a strategy for 3D culture of cryopreserved primary human hepatocytes in stirred-tank systems
SLAS Discovery
Arez F, Preiss L, Ramella Gal I, Rebelo SP, Badolo L, Brito C, Spangenberg T, Alves PM
2025
Vaccines Bioprocess Engineering
Virus-like particle vaccine with authentic quaternary epitopes protects against Zika virus-induced viremia and testicular damage
Journal of Virology
Abbo SR, Yan K, Geertsema C, Hick TAH, Altenburg JJ, Nowee G, van Toor C, van Lent JW, Nakayama E, Tang B, Metz SW, Bhowmik R, de Silva AM, Prow NA, Correia R, Alves PM, Roldão A, Martens DE, van Oers MM, Suhrbier A, Pijlman GP
2025
Advanced Cell Models for Drug Discovery and Translational Research
Engineering a Perfusion Bioreactor System for hiPSC‐Derived Progenitor Co‐Culture Capturing Microglial Features in CNS Development
Biotechnology and Bioengineering
Gomes CM, de Sá I, Delgado M, Alves PM, Brito C
2025
Advanced Technologies for Gene Therapy Products
Deciphering Key Adenoviral Elements in the Production of Recombinant Adeno-Associated Virus Vectors
Human Gene Therapy
Fernandes S, Guerra J, Ferreira MV, Coroadinha AS
2025
Natural Bioactives & Nutraceuticals
Unveiling the anti-inflammatory potential of 11β,13-dihydrolactucin for application in inflammatory bowel disease management
Food & Function
Matos MS, Ávila‑Gálvez MA, González‑Sarrías A, Silva NV, Lage Crespo C, Jacinto A, Serra AT, Matias AA, Nunes Dos Santos CND
2024
Protein Biophysics for Drug Discovery
The HSP90/R2TP Quaternary Chaperone Scaffolds Assembly of the TSC Complex
Journal of Molecular Biology
Abéza, C.; Busse, P.; Paiva, A. C. F.; Chagot, M.-E.; Schneider, J.; Robert, M.-C.; Vandermoere, F.; Schaeffer, C.; Charpentier, B.; Sousa, P. M. F.; Bandeiras, T. M.; Manival, X.; Cianferani, S.; Bertrand, E.; Verheggen, C.
2024
Microbiology and Molecular Biology
Beyond Harmful: Exploring Biofilm Formation by Enterococci Isolated from Portuguese Traditional Cheeses
Foods
Serrano S, Ferreira MV, Alves‑Barroco C, Morais S, Barreto‑Crespo MT, Tenreiro R, Semedo‑Lemsaddek T
2024
Natural Bioactives & Nutraceuticals
Exploring the Biological Potential of Hydroxytyrosol and Derivatives: Synthetic Strategies and Evaluation of Antiproliferative, Antioxidant, and Antimicrobial Activities
Journal of Agricultural and Food Chemistry
Martins, B. T.; Faria, N. A.; Macedo, A. C.; Miragaia, M.; Serra, A. T.; Bronze, M. R.; Ventura, M. R.
2024
Natural Bioactives & Nutraceuticals
A Novel Collagen Aerogel with Relevant Features for Topical Biomedical Applications
ChemPlusChem
Batista MP, Schroeter B, Fernández N, Gaspar FB, do Rosário Bronze M, Duarte AR, Gurikov P
2024
Bioengineering for Cell-based Therapies
Hypothermic and cryogenic preservation of cardiac tissue-engineered constructs
Biomaterials Science
Janssen J, Chirico N, Ainsworth MJ, Cedillo-Servin G, Viola M, Dokter I, Vermonden T, Doevendans PA, Serra M, Voets IK, Malda J, Castilho M, van Laake LW, Sluijter JPG, Sampaio-Pinto V, van Mil A
2024
Towards detection of structurally-diverse glycated epitopes in native proteins: Single-chain antibody directed to non-A1c epitope in human haemoglobin
Molecular Immunology
Gaetani ML, Pinto IC, Li M, O'Connor P, Giorgi-Coll S, Tyreman M, Rumary KL, Schouten JA, Davis P, Dixon AM
2024
Protein Biophysics for Drug Discovery
Discovery of reversible and covalent TEAD 1 selective inhibitors MSC-1254 and MSC-5046 based on one scaffold
Bioorganic & Medicinal Chemistry Letters
Carswell E, Heinrich T, Petersson C, Gunera J, Garg S, Schwarz D, Schlesiger S, Fischer F, Eichhorn T, Calder M, Smith G, MacDonald E, Wilson H, Hazel K, Trivier E, Broome R, Balsiger A, Sirohi S, Musil D, Freire F, Schilke H, Dillon C, Wienke D
2024