Publications

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Natural Bioactives & Nutraceuticals
Polymethoxylated Flavones Target Cancer Stemness and improve the Antiproliferative Effect of 5-Fluorouracil in a 3D Cell Model of Colorectal Cancer
Nutrients
C V Pereira, M Duarte, P Silva, A Bento da Silva, C M M Duarte, A Cifuentes, V García-Cañas, M R Bronze, C Albuquerque, A T Serra
2019
Vaccines Bioprocess Engineering
Process intensification for Peste des Petites Ruminants Virus vaccine production
 Vaccine
M Sousa , C Fenge, J Rupprecht, A Tappe, G Greller, P M Alves, M J T Carrondo, A Roldão
2019
Advanced Cell Models for Drug Discovery and Translational Research
Flexible 3D Cell-Based Platforms for the Discovery and Profiling of Novel Drugs Targeting Plasmodium Hepatic Infection
ACS Infect Dis.
F Arez, SP Rebelo, D Fontinha, D Simão, TR Martins, M Machado, C Fischli, C Oeuvray, L Badolo, MJT Carrondo, M Rottmann, T Spangenberg, C Brito, B Greco, M Prudêncio, PM Alves
2019
Advanced Technologies for Gene Therapy Products
Improved GaLV-TR Glycoproteins to Pseudotype Lentiviral Vectors: Impact of Viral Protease Activity in the Production of LV Pseudotypes
Molecular Therapy - Methods & Clinical Development
H A Tomás, D A Mestre, A F Rodrigues, M R Guerreiro, M J T Carrondo, A S Coroadinha
2019
Advanced Technologies for Gene Therapy Products
LentiPro26: novel stable cell lines for constitutive lentiviral vector production.
Natura Scientific Reports
HA Tomás, A F Rodrigues, M J T Carrondo MJT, A S Coroadinha
2018
Bioengineering for Cell-based Therapies
3D aggregate culture improves metabolic maturation of human pluripotent stem cell derived cardiomyocytes
Biotechnology and Bioengineering
Correia C, Koshkin A, Duarte P, Hu D, Carido M, Sebastião MJ, Gomes-Alves P, Elliott DA, Domian I, Teixeira AP, Alves PM, Serra M
2018
Protein Biophysics for Drug Discovery
The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones
Nature Communications
C Maurizy, M Quinternet, Y Abel, C Verheggen, PE Santo, M Bourguet, ACF Paiva, B Bragantini, M Chagot, M Robert, C Abeza, P Fabre, P Fort, F Vandermoere, PMF Sousa, JC Rain, B Charpentier, S Cianférani, TM Bandeiras, B Pradet-Balade, X Manival, E Bertrand
2018
Advanced Cell Models for Drug Discovery and Translational Research
Recapitulation of Human Neural Microenvironment Signatures in iPSC-Derived NPC 3D Differentiation.
Stem Cell Reports
Simão D, Silva MM, Terrasso AP, Arez F, Sousa MFQ, Mehrjardi NZ, Šarić T, Gomes-Alves P, Raimundo N, Alves PM, Brito C
2018
Bioengineering for Cell-based Therapies
Distinct carbon sources affect structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells
Nature Scientific Reports
Correia C, Koshkin A, Duarte P, Hu DJ, Teixeira AP, Domian IJ, Serra M. and Alves PM*
2017
In vitro expansion of human cardiac progenitor cells: exploring ’omics tools for characterization of cell-based allogeneic products
Translational Research
Gomes-Alves, P. and Serra, M. and Brito, C. and Ricardo, C.P. and Cunha, R. and Sousa, M.F. and Sanchez, B. and Bernad, A. and Carrondo, M.J.T. and Rodriguez-Borlado, L. and Alves, P.M.
2016
Natural Bioactives & Nutraceuticals
Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study
American Journal of Clinical Nutrition
S Silva, M R Bronze, M E Figueira, J Siwy, H Mischak, E Combet, W Mullen
2015
Bioengineering for Cell-based Therapies
Process engineering of human pluripotent stem cells for clinical application
Trends in Biotechnology
Serra M, Brito C, Correia C, Alves PM
2012
Advanced Technologies for Gene Therapy Products
Improvement of lentiviral transfer vectors using cis-acting regulatory elements for increased gene expression
Applied Microbiology and Biotechnology
Real, Gonçalo, and Monteiro, Francisca and Burger, Christa and Alves, Paula M.
2011
Advanced Technologies for Gene Therapy Products
Integrated Strategy for the Production of Therapeutic Retroviral Vectors
Human Gene Therapy
Carrondo, Manuel and Panet, Amos and Wirth, Dagmar and Coroadinha, Ana Sofia and Cruz, Pedro and Falk, Haya and Schucht, Roland and Dupont, Francis and Geny-Fiamma, Cécile and Merten, Otto-Wilhelm and Hauser, Hansjörg
2011
Analysis of adsorption of a baculovirus bioreaction bulk on an ion-exchange surface by surface plasmon resonance
Journal of Biotechnology
Vicente, Tiago and Mota, José P.B. and Peixoto, Cristina and Alves, Paula M. and Carrondo, Manuel J.T.
2010
Modeling electrostatic interactions of baculovirus vectors for ion-exchange process development
Journal of Chromatography A
Vicente, Tiago and Peixoto, Cristina and Alves, Paula M. and Carrondo, Manuel J.T.
2010
Modeling protein binding and elution over a chromatographic surface probed by surface plasmon resonance
Journal of Chromatography A
Vicente, Tiago and Mota, José P.B. and Peixoto, Cristina and Alves, Paula M. and Carrondo, Manuel J.T.
2010
An integrated analysis of enzyme activities, cofactor pools and metabolic fluxes in baculovirus-infected Spodoptera frugiperda Sf9 cells
Journal of Biotechnology
Bernal, Vicente and Monteiro, Francisca and Carinhas, Nuno and Ambrósio, Raquel and Alves, Paula M.
2010
Extending Hepatocyte Functionality for Drug-Testing Applications Using High-Viscosity Alginate–Encapsulated Three-Dimensional Cultures in Bioreactors
Tissue Engineering Part C: Methods
Miranda, Joana P. and Rodrigues, Armanda and Tostões, Rui M. and Leite, Sofia and Zimmerman, Heiko and Carrondo, Manuel J.T. and Alves, Paula M.
2010
Stirred bioreactors for the expansion of adult pancreatic stem cells
Annals of Anatomy - Anatomischer Anzeiger
Serra, Margarida and Brito, Catarina and Leite, Sofia B. and Gorjup, Erwin and von Briesen, Hagen and Carrondo, Manuel J.T. and Alves, Paula M.
2009
The effect of the cell death suppressor vMIA on the production of a recombinant protein in the adenovirus-293 expression system
Protein Expression and Purification
Vieira, Helena L.A. and Cunha, Liliana and Goldmacher, Victor S. and Alves, Paula M.
2009
Cryopreservation of Adherent Cells: Strategies to Improve Cell Viability and Function After Thawing
Tissue Engineering Part C: Methods
Malpique, Rita and Ehrhart, Friederike and Katsen-Globa, Alisa and Zimmermann, Heiko and Alves, Paula M.
2009
Anti‐inflammatory effect of Rosmarinic acid on a model of carrageenan‐induced paw edema
The FASEB Journal
Rocha, João Pedro and Sepodes, Bruno Miguel and Eduardo‐Figueira, Maria and Bronze, Rosário and Duarte, Catarina and Serra, Teresa and Silva‐Lima, Beatriz and Mota‐Filipe, Helder
2009
Advanced Cell Models for Drug Discovery and Translational Research
Towards an Extended Functional HepatocyteIn VitroCulture
Tissue Engineering Part C: Methods
Miranda, Joana P. and Leite, Sofia B. and Muller-Vieira, Ursula and Rodrigues, Armanda and Carrondo, Manuel J.T. and Alves, Paula M.
2009