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Bioengineering for Cell-based Therapies
Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays
ACS Biomaterials Science & Engineering
Paz-Artigas L, González-Lana S, Polo N, Vicente P, Montero-Calle P, Martínez MA, Rábago G, Serra M, Prósper F, Mazo MM, González A, Ochoa I, Ciriza J
2024
Protein Biophysics for Drug Discovery
Denaturing mass photometry for rapid optimization of chemical protein-protein cross-linking reactions
Nature Communications
Gizardin-Fredon H, Santo PE, Chagot ME, Charpentier B, Bandeiras TM, Manival X, Hernandez-Alba O, Cianférani S
2024
Natural Bioactives & Nutraceuticals
CO2-Based Encapsulation of Rutin-Rich Extracts from Black Elderberry Waste Using Advanced PGSS Process
Foods
Mutavski Z, Vidović S, Ambrus R, Šavikin K, Baixinho J, Fernández N, Nastić N
2024
Microbiology and Molecular Biology
Beyond Harmful: Exploring Biofilm Formation by Enterococci Isolated from Portuguese Traditional Cheeses
Foods
Serrano S, Ferreira MV, Alves‑Barroco C, Morais S, Barreto‑Crespo MT, Tenreiro R, Semedo‑Lemsaddek T
2024
Bioengineering for Cell-based Therapies
A roadmap towards manufacturing extracellular vesicles for cardiac repair
Trends in Biotechnology
Louro AF, Meliciano A, Alves PM, Costa MHG, Serra M
2024
Advanced Cell Models for Drug Discovery and Translational Research
Miniaturization of hiPSC-derived 3D neural cultures in stirred-tank bioreactors for parallelized preclinical assessment of rAAV
Frontiers in Bioengineering and Biotechnology
Gomes CM, Sebastião MJ, Silva G, Moura F, Simão D, Gomes-Alves P, Alves PM, Brito C
2024
Protein Biophysics for Drug Discovery
On the humanization of VHHs: Prospective case studies, experimental and computational characterization of structural determinants for functionality
Protein Science
Fernández‑Quintero ML, Guarnera E, Musil D, Pekar L, Sellmann C, Freire F, Sousa RL, Santos SP, Freitas MC, Bandeiras TM, Silva MMS, Loeffler JR, Ward AB, Harwardt J, Zielonka S, Evers A
2024
Protein Biophysics for Drug Discovery
SARS-CoV2 Nsp1 is a metal-dependent DNA and RNA endonuclease
BioMetals
Salgueiro BA, Saramago M, Tully MD, Issoglio F, Silva STN, Paiva ACF, Arraiano CM, Matias PM, Matos RG, Moe E, Romão CV
2024
Protein Biophysics for Drug Discovery
Identification of novel candidate predisposing genes in familial nonmedullary thyroid carcinoma implicating DNA damage repair pathways
International Journal of Cancer
Pires C, Marques IJ, Saramago A, Moura MM, Pojo M, Cabrera R, Santos C, Rosário F, Lousa D, Vicente JB, Bandeiras TM, Teixeira MR, Leite V, Cavaco BM
2024
Protein Biophysics for Drug Discovery
MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686
Journal of Medicinal Chemistry
Heinrich T, Schwarz D, Petersson C, Gunera J, Garg S, Schneider R, Keil M, Grimmeisen L, Unzue Lopez A, Albers L, Schlesiger S, Gambardella A, Bomke J, Carswell E, Schilke H, Diehl P, Doerfel B, Musil D, Trivier E, Broome R, Marshall S, Balsiger A, Friedrich E, Lemos AR, Santos SP, Sousa PMF, Freire F, Bandeiras TM, Bortoluzzi A, Wienke D
2024
Protein Biophysics for Drug Discovery
Aldehyde Dehydrogenase 2 (ALDH2): A novel sorafenib target in hepatocellular carcinoma unraveled by the proteome-wide cellular thermal shift assay
SLAS Discovery
Ferreira IC, Torrejón E, Abecasis B, Alexandre BM, Gomes RA, Verslype C, van Pelt J, Barbas A, Simão D, Bandeiras TM, Bortoluzzi A, Rebelo SP
2024
Microbiology and Molecular Biology
Whole genome sequence of Paracoccus sp. NFXS7, a carotenoid-producing bacterium isolated from a marine saltern
Access Microbiology
Bertrand CDF, Martins R, Quintas-Nunes F, Reynolds-Brandão P, Crespo MTB, Nascimento FX
2024
Microbiology and Molecular Biology
Whole-genome sequences of marine bacteria presenting the ability to promote the growth of the diatom Phaeodactylum tricornutum
Access Microbiology
Martins R, Bertrand CDF, Quintas‑Nunes F, Reynolds‑Brandão P, Barreto Crespo MT, Nascimento FX
2024
Circulating low-molecular-weight (poly)phenol metabolites in the brain: unveiling in vitro and in vivo blood–brain barrier transport
Food & Function
Carecho, R.; Marques, D.; Carregosa, D.; Masuero, D.; Garcia-Aloy, M.; Tramer, F.; Passamonti, S.; Vrhovsek, U.; Ventura, M. R.; Brito, M. A.; Nunes dos Santos, C.; Figueira, I.
2024
Towards detection of structurally-diverse glycated epitopes in native proteins: Single-chain antibody directed to non-A1c epitope in human haemoglobin
Molecular Immunology
Gaetani ML, Pinto IC, Li M, O'Connor P, Giorgi-Coll S, Tyreman M, Rumary KL, Schouten JA, Davis P, Dixon AM
2024
Advanced Technologies for Gene Therapy Products
Accelerated Development of AAV Purification Process Using a High-Throughput and Automated Crossflow System
Separations
Mendes, Sónia and Faria, Tiago Q. and Nascimento, André and Noverraz, Marc and Bollmann, Franziska and Nestola, Piergiuseppe and Roldão, António and Peixoto, Cristina and Silva, Ricardo J. S.
2024
Vaccines Bioprocess Engineering
Boosting Vaccine Research: The 16-Year Journey of TRANSVAC Vaccine Infrastructure
Vaccines
Martin W, Luís C, Jungbluth S, Slezak M, Verreck FAW, Spiegel H, Guzman CA, Roldão A, Carrondo MJT, Van der Ley P, Segalés J, Dockrell HM, Ho MM, Pedersen GK, Lawrenz M, Olesen OF
2024
Microbiology and Molecular Biology
Sustainable production of nanoemulsions by membrane-assisted nanoemulsification using novel aroma-based hydrophobic deep eutectic solvents for enhanced antifungal activities.
Journal of Cleaner Production
S Mondal, U T Syed, E Pinto, I C Leonardo, P Romero, F B Gaspar, M T Barreto Crespo, V Sebastian, J G Crespo, C Brazinha
2024
Bioengineering for Cell-based Therapies
Hypothermic and cryogenic preservation of cardiac tissue-engineered constructs
Biomaterials Science
Janssen J, Chirico N, Ainsworth MJ, Cedillo-Servin G, Viola M, Dokter I, Vermonden T, Doevendans PA, Serra M, Voets IK, Malda J, Castilho M, van Laake LW, Sluijter JPG, Sampaio-Pinto V, van Mil A
2024
Microbiology and Molecular Biology
Whole genome sequences of marine bacteria presenting the ability to promote the growth of the diatom Phaeodactylum tricornutum
Microbiology Society
Martins, R.; Bertrand, C.; Quintas-Nunes, F.; Reynolds-Brandão, P.; Barreto Crespo, M.; Nascimento, F. X.
2024
Microbiology and Molecular Biology
Genomic insights into indole-3-acetic acid catabolism in the marine algae-associated bacterium, Marinomonas sp. NFXS50
Access Microbiology
Bertrand C, Martins R, Nunes F, Brandão P, Nascimento FX
2024
Natural Bioactives & Nutraceuticals
Unveiling the anti-inflammatory potential of 11β,13-dihydrolactucin for application in inflammatory bowel disease management
Food & Function
Matos MS, Ávila‑Gálvez MA, González‑Sarrías A, Silva NV, Lage Crespo C, Jacinto A, Serra AT, Matias AA, Nunes Dos Santos CND
2024
Identification of Mispairing Omic Signatures in Chinese Hamster Ovary (CHO) Cells Producing a Tri-Specific Antibody
Biomedicines
Sebastião MJ, Hoffman M, Escandell J, Tousi F, Zhang J, Figueroa B, DeMaria C, Gomes-Alves P
2023
Vaccines Bioprocess Engineering
Potential business model for a European vaccine R&D infrastructure and its estimated socio-economic impact
F1000Research
Jungbluth S, Martin W, Slezak M, Depraetere H, Guzman CA, Ussi A, Morrow D, Van Heuverswyn F, Arnouts S, Carrondo MJT, Olesen O, Ottenhoff THM, Dockrell HM, Ho MM, Dobly A, Christensen D, Segalés J, Laurent F, Lantier F, Stockhofe‑Zurwieden N, Morelli F, Langermans JAM, Verreck FAW, Le Grand R, Sloots A, Medaglini D, Lawrenz M, Collin N
2023