Publications

In vitro expansion of human cardiac progenitor cells: exploring ’omics tools for characterization of cell-based allogeneic products

Translational Research

Gomes-Alves, P. and Serra, M. and Brito, C. and Ricardo, C.P. and Cunha, R. and Sousa, M.F. and Sanchez, B. and Bernad, A. and Carrondo, M.J.T. and Rodriguez-Borlado, L. and Alves, P.M.

2016

Natural Bioactives & Nutraceuticals

Production of a natural red pigment derived from Opuntia spp. using a novel high pressure CO2assisted-process

RSC Advances

Nunes, A. N.; Saldanha do Carmo, C.; Duarte, C. M. M.

2015

Natural Bioactives & Nutraceuticals

Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study

American Journal of Clinical Nutrition

S Silva, M R Bronze, M E Figueira, J Siwy, H Mischak, E Combet, W Mullen

2015

Bioengineering for Cell-based Therapies

Robust Expansion of Human Pluripotent Stem Cells: Integration of Bioprocess Design With Transcriptomic and Metabolomic Characterization

Stem Cells Translational Medicine

Silva, M. M.; Rodrigues, A. F.; Correia, C.; Sousa, M. F. Q.; Brito, C.; Coroadinha, A. S.; Serra, M.; Alves, P. M.

2015

Bioengineering for Cell-based Therapies

Production of oncolytic adenovirus and human mesenchymal stem cells in a single‐use, Vertical‐Wheel bioreactor system: Impact of bioreactor design on performance of microcarrier‐based cell culture processes

Biotechnology Progress

Sousa, M. F. Q.; Silva, M. M.; Giroux, D.; Hashimura, Y.; Wesselschmidt, R.; Lee, B.; Roldão, A.; Carrondo, M. J. T.; Alves, P. M.; Serra, M.

2015

Bioengineering for Cell-based Therapies

Three-dimensional co-culture of human hepatocytes and mesenchymal stem cells: improved functionality in long-term bioreactor cultures: 3D co-cultures of human hepatocytes and MSCs in bioreactors

Journal of Tissue Engineering and Regenerative Medicine

Rebelo, S. P.; Costa, R.; Silva, M. M.; Marcelino, P.; Brito, C.; Alves, P. M.

2015

Bioengineering for Cell-based Therapies

Exploring analytical proteomics platforms toward the definition of human cardiac stem cells receptome

Proteomics

Gomes-Alves, P.; Serra, M.; Brito, C.; R.-Borlado, L.; López, J. A.; Vázquez, J.; Carrondo, M. J. T.; Bernad, A.; Alves, P. M.

2015

Protein Biophysics for Drug Discovery

Microdosing of a Carbon‐14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages

Clinical Pharmacology & Therapeutics

Vlaming, M. L. H.; van Duijn, E.; Dillingh, M. R.; Brands, R.; Windhorst, A. D.; Hendrikse, N. H.; Bosgra, S.; Burggraaf, J.; de Koning, M. C.; Fidder, A.; Mocking, J. A. J.; Sandman, H.; de Ligt, R. A. F.; Fabriek, B. O.; Pasman, W. J.; Seinen, W.; Alves, T.; Carrondo, M.; Peixoto, C.; Peeters, P. A. M.; Vaes, W. H. J.

2015

Bioengineering for Cell-based Therapies

Stem Cell-Derived Systems in Toxicology Assessment

Stem Cells and Development

Suter-Dick, L.; Alves, P. M.; Blaauboer, B. J.; Bremm, K.-D.; Brito, C.; Coecke, S.; Flick, B.; Fowler, P.; Hescheler, J.; Ingelman-Sundberg, M.; Jennings, P.; Kelm, J. M.; Manou, I.; Mistry, P.; Moretto, A.; Roth, A.; Stedman, D.; van de Water, B.; Beilmann, M.

2015

Advanced Technologies for Gene Therapy Products

Bioactive transparent films based on polysaccharides and cholinium carboxylate ionic liquids

Green Chemistry

Tomé, L. C.; Silva, N. H. C. S.; Soares, H. R.; Coroadinha, A. S.; Sadocco, P.; Marrucho, I. M.; Freire, C. S. R.

2015

Advanced Cell Models for Drug Discovery and Translational Research

Modeling Human Neural FunctionalityIn Vitro: Three-Dimensional Culture for Dopaminergic Differentiation

Tissue Engineering Part A

Simão, D.; Pinto, C.; Piersanti, S.; Weston, A.; Peddie, C. J.; Bastos, A. E. P.; Licursi, V.; Schwarz, S. C.; Collinson, L. M.; Salinas, S.; Serra, M.; Teixeira, A. P.; Saggio, I.; Lima, P. A.; Kremer, E. J.; Schiavo, G.; Brito, C.; Alves, P. M.

2015

Microbiology and Molecular Biology

Annual ryegrass-associated bacteria with potential for plant growth promotion

Microbiological Research

Castanheira, N.; Dourado, A. C.; Alves, P. I.; Cortés-Pallero, A. M.; Delgado-Rodríguez, A. I.; Prazeres, Â.; Borges, N.; Sánchez, C.; Barreto Crespo, M. T.; Fareleira, P.

2014

Natural Bioactives & Nutraceuticals

Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis

Food Funct.

Figueira, M. E.; Câmara, M. B.; Direito, R.; Rocha, J.; Serra, A. T.; Duarte, C. M. M.; Fernandes, A.; Freitas, M.; Fernandes, E.; Marques, M. C.; Bronze, M. R.; Sepodes, B.

2014

Natural Bioactives & Nutraceuticals

Anti‐inflammatory Effect of Rosmarinic Acid and an Extract of Rosmarinus officinalis in Rat Models of Local and Systemic Inflammation

Basic & Clinical Pharmacology & Toxicology

Rocha, J.; Eduardo‐Figueira, M.; Barateiro, A.; Fernandes, A.; Brites, D.; Bronze, R.; Duarte, C. M. M.; Serra, A. T.; Pinto, R.; Freitas, M.; Fernandes, E.; Silva‐Lima, B.; Mota‐Filipe, H.; Sepodes, B.

2014

Bioengineering for Cell-based Therapies

Metabolic responses of CHO cells to limitation of key amino acids

Biotechnology and Bioengineering

Duarte, T. M.; Carinhas, N.; Barreiro, L. C.; Carrondo, M. J. T.; Alves, P. M.; Teixeira, A. P.

2014

Bioengineering for Cell-based Therapies

Process engineering of human pluripotent stem cells for clinical application

Trends in Biotechnology

Serra M, Brito C, Correia C, Alves PM

2012

Advanced Technologies for Gene Therapy Products

Integrated Strategy for the Production of Therapeutic Retroviral Vectors

Human Gene Therapy

Carrondo, Manuel and Panet, Amos and Wirth, Dagmar and Coroadinha, Ana Sofia and Cruz, Pedro and Falk, Haya and Schucht, Roland and Dupont, Francis and Geny-Fiamma, Cécile and Merten, Otto-Wilhelm and Hauser, Hansjörg

2011

Advanced Technologies for Gene Therapy Products

Improvement of lentiviral transfer vectors using cis-acting regulatory elements for increased gene expression

Applied Microbiology and Biotechnology

Real, Gonçalo, and Monteiro, Francisca and Burger, Christa and Alves, Paula M.

2011

Advanced Technologies for Gene Therapy Products

Manufacturing of Retroviruses

Humana Press

Cruz, P. E.; Rodrigues, T.; Carmo, M.; Wirth, D.; Amaral, A. I.; Alves, P. M.; Coroadinha, A. S.

2011

Analysis of adsorption of a baculovirus bioreaction bulk on an ion-exchange surface by surface plasmon resonance

Journal of Biotechnology

Vicente, Tiago and Mota, José P.B. and Peixoto, Cristina and Alves, Paula M. and Carrondo, Manuel J.T.

2010

Modeling electrostatic interactions of baculovirus vectors for ion-exchange process development

Journal of Chromatography A

Vicente, Tiago and Peixoto, Cristina and Alves, Paula M. and Carrondo, Manuel J.T.

2010

Modeling protein binding and elution over a chromatographic surface probed by surface plasmon resonance

Journal of Chromatography A

Vicente, Tiago and Mota, José P.B. and Peixoto, Cristina and Alves, Paula M. and Carrondo, Manuel J.T.

2010

An integrated analysis of enzyme activities, cofactor pools and metabolic fluxes in baculovirus-infected Spodoptera frugiperda Sf9 cells

Journal of Biotechnology

Bernal, Vicente and Monteiro, Francisca and Carinhas, Nuno and Ambrósio, Raquel and Alves, Paula M.

2010

Extending Hepatocyte Functionality for Drug-Testing Applications Using High-Viscosity Alginate–Encapsulated Three-Dimensional Cultures in Bioreactors

Tissue Engineering Part C: Methods

Miranda, Joana P. and Rodrigues, Armanda and Tostões, Rui M. and Leite, Sofia and Zimmerman, Heiko and Carrondo, Manuel J.T. and Alves, Paula M.

2010