MSCA Doctoral Network CAARE: Characterization and Recovery of Bionanoparticles for Vaccine Delivery and Gene Therapy

CAARE (Characterization and Analysis of Advanced biotherapeutics through Robust Engineering) is a Marie Sklodowska-Curie Doctoral Network bringing together leading experts to advance downstream processing and analytical technologies for bionanoparticle manufacturing.

This network is dedicated to:

• Enhancing the characterization of bionanoparticles during production, employing cutting edge analytical techniques;
• Improving the safety and efficacy of bionanoparticles-based therapies;
• Developing more efficient, scalable, and cost-effective manufacturing processes.

A key focus of CAARE is the development of intensified downstream processes to eliminate impurities and defective particles, ensuring the production of high-purity, high-potency therapeutic products.

The program will train 14 Doctoral Candidates in advanced bioprocessing and state-of-the-art analytical methodologies, equipping them with the skills needed to drive future innovations in biopharmaceutical manufacturing.

The CAARE consortium includes seven leading research institutions and nine associated partners, six of which are from the biopharmaceutical industry.

iBET’s Participation in CAARE

iBET is one of the seven partners in the consortium and a host institution for two of the doctoral projects.

Doctoral Project 13 – “Impact of continuous downstream process in complex biotherapeutic particles manufacturing”

This project aims to transition traditional batch purification steps for viral particles into a continuous purification process with improved environmental foot-print and economic metrics.

Doctoral Project 14 – “Scale-up strategies for purification of bionanoparticles”

This research will focus on developing a simple scalable purification process for adeno-associated virus, from benchtop to industrial scale, including comprehensive characterization of the particles at each stage.

This project has received funding from the European Union’s Horizon Europe research and innovation programme under the Marie Skłodowska Curie grant agreement N 101168862.