Publications

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High-throughput flow cytometry-based titration of a live attenuated rotavirus vaccine
Journal of Biotechnology
Dias MM, Carvalho SB, Matheise JP, Van Beersel G, Knott I, Gomes-Alves P, Alves PM
2025
Advanced Cell Models for Drug Discovery and Translational Research
Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids
iScience
Gomes CM, Simão D, Gonçalves CC, Silva G, Painho B, Alves PM, Brito C
2025
Bioengineering for Cell-based Therapies
Heterotypic spheroids as a strategy for 3D culture of cryopreserved primary human hepatocytes in stirred-tank systems
SLAS Discovery
Arez F, Preiss L, Ramella Gal I, Rebelo SP, Badolo L, Brito C, Spangenberg T, Alves PM
2025
Vaccines Bioprocess Engineering
Virus-like particle vaccine with authentic quaternary epitopes protects against Zika virus-induced viremia and testicular damage
Journal of Virology
Abbo SR, Yan K, Geertsema C, Hick TAH, Altenburg JJ, Nowee G, van Toor C, van Lent JW, Nakayama E, Tang B, Metz SW, Bhowmik R, de Silva AM, Prow NA, Correia R, Alves PM, Roldão A, Martens DE, van Oers MM, Suhrbier A, Pijlman GP
2025
Advanced Cell Models for Drug Discovery and Translational Research
Engineering a Perfusion Bioreactor System for hiPSC‐Derived Progenitor Co‐Culture Capturing Microglial Features in CNS Development
Biotechnology and Bioengineering
Gomes CM, de Sá I, Delgado M, Alves PM, Brito C
2025
Advanced Technologies for Gene Therapy Products
Deciphering Key Adenoviral Elements in the Production of Recombinant Adeno-Associated Virus Vectors
Human Gene Therapy
Fernandes S, Guerra J, Ferreira MV, Coroadinha AS
2025
Vaccines Bioprocess Engineering
Continuous Production of Influenza VLPs Using IC‐BEVS and Multi‐Stage Bioreactors
Biotechnology and Bioengineering
Correia R, Zotler T, Ferraz F, Fernandes B, Graça M, Pijlman GP, Alves PM, Roldão A
2025
Advanced Technologies for Gene Therapy Products
Developing a robust and scalable platform for AAV8 production
Journal of Biotechnology
Nascimento A, Faria TQ, Nunes T, Oliveira JG, Mendes J, Roldão A, Peixoto C
2025
Vaccines Bioprocess Engineering
Modifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune response in a mouse model
Communications Medicine
Renner TM, Stuible M, Rossotti MA, Rohani N, Cepero-Donates Y, Sauvageau J, Deschatelets L, Dudani R, Harrison BA, Baardsnes J, Koyuturk I, St. Michael F, Hill JJ, Hemraz UD, Lenferink AEG, Tanha J, Fernandes B, Roldao A, McCluskie MJ, Akache B, Durocher Y
2025
Bioengineering for Cell-based Therapies
Controlled activation modulates T-cell expansion and phenotype in stirred-tank bioreactors
Cytotherapy
Costa MS, Costa CM, Matos LN, Sebastião MJ, Duarte N, Costa MHG, Serra M
2025
Natural Bioactives & Nutraceuticals
Optimization of Supercritical Fluid Extraction for the Recovery of γ-Oryzanol-Rich Extracts with Improved Bioactivity from Rice Bran
Antioxidants
Baixinho JP, Cardeira M, Bento-Silva A, Partidário AMC, Serra AT, Bronze MR, Fernández N
2025
Protein Biophysics for Drug Discovery
Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor
Journal of Medicinal Chemistry
Mann SE, Lefranc J, Alkhatib O, Boivin R, Bomke J, Byrne RT, Cassona CP, Chen X, Cornaciu I, Costales P, Davis OA, DeSelm L, Elinati E, Follows B, Galbiati A, Göldner C, Hayre JK, Jorand-Lebrun C, Lademann CA, Leuthner B, Majithiya JB, Malta CF, Mason B, McWhirter CL, Neff B, Nissink JWM, Pehl U, Petersson C, Pica A, Pinto MF, Rajendra E, Rakers C, Toste Rêgo A, Robinson HMR, Sala-Hojman A, Schaedler TA, Schürmann PJL, Silva DO, Smith GCM, Sorrell F, Webster GR, Zenke FT, Heald RA, Burgdorf LT
2025
Microbiology and Molecular Biology
Beyond guaiacol and halophenols: Unravelling isobutyric and isovaleric acids as new culprits in off-flavour spoilage by Alicyclobacillus spp.
International Journal of Food Microbiology
Leonardo IC, Ferreira A, Bronze MR, Quendera AP, Fernandes AF, Barreto Crespo MT, Bustos Gaspar F
2025
Microbiology and Molecular Biology
From Dormancy to Eradication: Strategies for Controlling Bacterial Persisters in Food Settings
Foods
Serrano S, Grujović MŽ, Marković KG, Barreto-Crespo MT, Semedo-Lemsaddek T
2025
Asparagopsis taxiformis Feed Supplementation as a Tool to Improve the Resilience of Farmed Diplodus sargus to Marine Heatwave Events—A Metabolomics Approach
Fishes
Dias M, Marmelo I, António C, Rodrigues AM, Marques A, Diniz MS, Maulvault AL
2025
Advanced Technologies for Gene Therapy Products
Purification of AAV8 through a scalable two-step monolithic chromatography approach
Journal of Chromatography A
Nascimento A, Faria TQ, Bollmann F, Noverraz M, Pressac G, Roldão A, Peixoto C, Silva RJS
2025
Microbiology and Molecular Biology
Treatment of wastewater effluents using nanofiltration and low pressure UV photolysis to produce high quality water for food production
Water Research
Cristóvão MB, Sério J, Marques AP, Bento-Silva A, Gossard M, Vergara-Diaz O, Silva AF, Nunes M, Bronze MR, de Oliveira PB, Crespo MTB, Crespo JG, Pereira VJ
2025
Advanced Technologies for Gene Therapy Products
Advancing cystic fibrosis treatment: investigational agents on the horizon
Expert Opinion on Pharmacotherapy
Santos L, Camargo M, Terlizzi V, Lopes-Pacheco M
2025
Microbiology and Molecular Biology
Integration of spectroscopic techniques and machine learning for optimizing Phaeodactylum tricornutum cell and fucoxanthin productivity
Bioresource Technology
Reynolds-Brandão P, Quintas-Nunes F, Bertrand CF, Martins RM, Crespo MTB, Galinha CF, Nascimento FX
2025
Bioengineering for Cell-based Therapies
Engineering Characterization of Small‐Scale Bioreactors for Large‐Scale hiPSC Production
Biotechnology Journal
Vicente P, Meliciano A, Diniz C, Charalambidou A, Terrasso AP, Freitas C, Ducci A, Alves PM, Micheletti M, Roldão A, Serra M
2025
Vaccines Bioprocess Engineering
Engineered thermoswitch in the baculovirus expression vector system for production of virus-like particle vaccines with minimized baculovirus contaminants
Trends in Biotechnology
van Oosten L, Altenburg JJ, Nowee G, Kenbeek D, Neef T, Rouw T, Tegelbeckers VIP, van der Heijden J, Mentink S, Willemsen W, Hausjell CS, Kuijpers L, van der Pol L, Roldão A, Correia R, van den Born E, Wijffels RH, Martens DE, van Oers MM, Pijlman GP
2025
Streamlining the purification of a clinical-grade oncolytic virus for therapeutic applications
Separation and Purification Technology
Fernandes RP, Göbel S, Reiter M, Bryan A, Altomonte J, Genzel Y, Peixoto C
2025
Vaccines Bioprocess Engineering
Baculovirus-mediated production and purification of ferritin nanoparticles for rift valley fever vaccine development
Journal of Biological Engineering
Rodrigues MQ, Tambaclal A, Kloss B, Alves PM, Roldão A
2025
Natural Bioactives & Nutraceuticals
Matching the Sensory Analysis of Serpa PDO Cheese with the Volatile Profiles—A Preliminary Study
Foods
Macedo A, Carvalho MJ, Mecha E, Costa L, Ferreira A, Inácio RS, Bronze MDR
2025