Publications

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Bioproduction
Evaluation of gene editing in CHO cells using the Cas-CLOVER system
Biotechnology Progress
McLamarrah T, Aral E, Hoffman M, Tedstone J, King T, Vitko J, Sebastião MJ, Escandell JM, Dias MM, McCall I, Machado D, Cairns V, DeMaria C, Scarcelli JJ
2026
Protein Biophysics for Drug Discovery
CNS penetrant TEAD1,2,4 inhibitor MSC-4070 derived from phenotypic screening hit optimization
RSC Medicinal Chemistry
Heinrich T, Petersson C, Gunera J, Gambardella A, Schwarz D, Garg S, Schilke H, Weitzel T, Kolb C, Anlauf U, Reither V, Rettig C, Opelt B, Delp A, Wildner N, Sousa PMF, Freire F, Bandeiras TM, Wienke D
2026
Bioproduction
An improved CRISPR-Cas9 protein-based method for knocking out insect Sf9 cell genes
Applied Microbiology and Biotechnology
Graça M, Virgolini N, Correia R, Escandell J, Roldão A
2026
Bioengineering for Cell-based Therapies
Scaling the manufacture of adipose tissue-derived mesenchymal stromal cells: integrated bioreactor workflows from inoculation to harvest without the need of seed train
BMC Biotechnology
Costa MHG, Terrasso AP, Crespo IE, Valero R, Menéndez B, Painho B, Sousa CD, Gamelas B, Tomás H, Mancheno‑Corvo P, Menta R, Gugel CR, Fernández‑Gómez V, Herrero‑Méndez Á, Mármol IZ, Avivar‑Valderas A, Pérez LM, Rosa O de la, Lombardo E, Serra M, Ortiz‑Virumbrales M
2026
Advanced Technologies for Gene Therapy Products
Enhancing gene therapy vectors manufacturing: CEBPA as a master regulator of rAAV biogenesis
Journal of Biological Engineering
Moura F, Antunes M, Correia R, Roldão A, Gomes‑Alves P, Alves PM, Escandell JM
2026
Advanced Technologies for Gene Therapy Products
Streamlined rAAV HeLaS3 producer cell line generation via GS selection
Scientific Reports
Antunes M, Moura F, Sebastian IR, Alves P, Gomes‑Alves P, Escandell JM
2026
Natural Bioactives & Nutraceuticals
Valorization of Olive Stones: Chemical Composition and Bioactivity
Pharmaceuticals
Nunes, Bruna and Fernández, Naiara and Bento Silva, Andreia and Partidário, Ana and Marto, Joana and Alexandre, Elisabete M. C. and Lourenço, Sofia and Serra, Ana Teresa and Bronze, Maria Rosário and Duarte, Noélia and Rodrigues, Ana Margarida
2026
Vaccines Bioprocess Engineering
Ferritin nanoparticles displaying rift valley fever virus glycoprotein elicit potent dendritic cell activation in vitro
Virology Journal
Rodrigues MQ, Cardoso I, Duarte N, Alves PM, Roldão A
2026
Microbiology and Molecular Biology
Sustainable Disinfection of Horticulture Industry Water Using UV-C Light-Emitting Diodes
Sustainability
Ferreira N, Marques AP, Silva MC, Barreto Crespo MT, Pereira VJ
2026
Advanced Technologies for Gene Therapy Products
Development of a serum-free producer cell line generation process for scalable and efficient rAAV production for gene therapy applications
Journal of Biotechnology
Escandell JM, Dias M, Gonçalves M, Pais D, Conceição A, Mathur A, Balva B, Sen S, Figueroa B, Vincent KA, Gomes-Alves P
2026
Protein Biophysics for Drug Discovery
Structure-based design of pyrazole derivatives targeting the human Cyclophilin D binding site
International Journal of Biological Macromolecules
Silva, Diana O. and Freitas, Micael C. and Malta, Catarina F. and Martins, Madalena T. and Sousa, Pedro M.F. and Matias, Pedro M. and Schwarz, Daniel and Ventura, M. Rita and Grädler, Ulrich and Bandeiras, Tiago M.
2026
Protein Biophysics for Drug Discovery
An integrative structural biology approach reveals the dynamic organization of the R2SP quaternary chaperone complex
Nature Communications
Santo PE, Chagot M‑E, Gizardin‑Fredon H, Ley M, Chenuel T, Deslignière E, Plassart L, Paiva ACF, Sousa PMF, Bertrand E, Charpentier B, Verheggen C, Quinternet M, Meyer P, Bandeiras TM, Cianférani S, Plisson‑Chastang C, Manival X
2026
Natural Bioactives & Nutraceuticals
Optimization of Supercritical Fluid Extraction for the Recovery of γ-Oryzanol-Rich Extracts with Improved Bioactivity from Rice Bran
Antioxidants
Baixinho JP, Cardeira M, Bento-Silva A, Partidário AMC, Serra AT, Bronze MR, Fernández N
2025
Improving AAV8 purification with continuous affinity capture: From batch to continuous multicolumn chromatography
Journal of Biotechnology
Neto S, Rankine G, Bollmann F, Carrondo MJT, Silva RJS
2025
Natural Bioactives & Nutraceuticals
Storage Time in Bottle: Influence on Physicochemical and Phytochemical Characteristics of Wine Spirits Aged Using Traditional and Alternative Technologies
Molecules
Oliveira-Alves SC, Fernandes TA, Lourenço S, Granja-Soares J, Silva AB, Bronze MR, Catarino S, Canas S
2025
Vaccines Bioprocess Engineering
Continuous Production of Influenza VLPs Using IC‐BEVS and Multi‐Stage Bioreactors
Biotechnology and Bioengineering
Correia R, Zotler T, Ferraz F, Fernandes B, Graça M, Pijlman GP, Alves PM, Roldão A
2025
Advanced Technologies for Gene Therapy Products
Developing a robust and scalable platform for AAV8 production
Journal of Biotechnology
Nascimento A, Faria TQ, Nunes T, Oliveira JG, Mendes J, Roldão A, Peixoto C
2025
Protein Biophysics for Drug Discovery
An engineered cereblon optimized for high-throughput screening and molecular glue discovery
Cell Chemical Biology
Bailey HJ, Eisert J, Kazi R, Gerhartz J, Pieńkowska DE, Dressel I, Vollrath J, Kondratov I, Matviyuk T, Tolmachova N, Shah VJ, Giuliani G, Mosler T, Geiger TM, Esteves AM, Santos SP, Sousa RL, Bandeiras TM, Leibrock EM, Bauer U, Leuthner B, Langer JD, Wegener AA, Nowak RP, Sorrell FJ, Dikic I
2025
Advanced Technologies for Gene Therapy Products
Advancing cystic fibrosis treatment: investigational agents on the horizon
Expert Opinion on Pharmacotherapy
Santos L, Camargo M, Terlizzi V, Lopes-Pacheco M
2025
Advanced Technologies for Gene Therapy Products
Deciphering Key Adenoviral Elements in the Production of Recombinant Adeno-Associated Virus Vectors
Human Gene Therapy
Fernandes S, Guerra J, Ferreira MV, Coroadinha AS
2025
Bioengineering for Cell-based Therapies
Engineering Characterization of Small‐Scale Bioreactors for Large‐Scale hiPSC Production
Biotechnology Journal
Vicente P, Meliciano A, Diniz C, Charalambidou A, Terrasso AP, Freitas C, Ducci A, Alves PM, Micheletti M, Roldão A, Serra M
2025
Natural Bioactives & Nutraceuticals
Collagen–Chitosan Composites Enhanced with Hydroxytyrosol for Prospective Wound Healing Uses
Pharmaceutics
Batista MP, Pimenta M, Fernández N, Duarte ARC, Bronze MR, Marto J, Gaspar FB
2025
Asparagopsis taxiformis Feed Supplementation as a Tool to Improve the Resilience of Farmed Diplodus sargus to Marine Heatwave Events—A Metabolomics Approach
Fishes
Dias M, Marmelo I, António C, Rodrigues AM, Marques A, Diniz MS, Maulvault AL
2025
Vaccines Bioprocess Engineering
Modifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune response in a mouse model
Communications Medicine
Renner TM, Stuible M, Rossotti MA, Rohani N, Cepero-Donates Y, Sauvageau J, Deschatelets L, Dudani R, Harrison BA, Baardsnes J, Koyuturk I, St. Michael F, Hill JJ, Hemraz UD, Lenferink AEG, Tanha J, Fernandes B, Roldao A, McCluskie MJ, Akache B, Durocher Y
2025