Publications

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Advanced Technologies for Gene Therapy Products
Development of a serum-free producer cell line generation process for scalable and efficient rAAV production for gene therapy applications
Journal of Biotechnology
Escandell JM, Dias M, Gonçalves M, Pais D, Conceição A, Mathur A, Balva B, Sen S, Figueroa B, Vincent KA, Gomes-Alves P
2026
Protein Biophysics for Drug Discovery
An integrative structural biology approach reveals the dynamic organization of the R2SP quaternary chaperone complex
Nature Communications
Santo PE, Chagot M‑E, Gizardin‑Fredon H, Ley M, Chenuel T, Deslignière E, Plassart L, Paiva ACF, Sousa PMF, Bertrand E, Charpentier B, Verheggen C, Quinternet M, Meyer P, Bandeiras TM, Cianférani S, Plisson‑Chastang C, Manival X
2026
Bioproduction
Evaluation of gene editing in CHO cells using the Cas-CLOVER system
Biotechnology Progress
McLamarrah T, Aral E, Hoffman M, Tedstone J, King T, Vitko J, Sebastião MJ, Escandell JM, Dias MM, McCall I, Machado D, Cairns V, DeMaria C, Scarcelli JJ
2026
Protein Biophysics for Drug Discovery
CNS penetrant TEAD1,2,4 inhibitor MSC-4070 derived from phenotypic screening hit optimization
RSC Medicinal Chemistry
Heinrich T, Petersson C, Gunera J, Gambardella A, Schwarz D, Garg S, Schilke H, Weitzel T, Kolb C, Anlauf U, Reither V, Rettig C, Opelt B, Delp A, Wildner N, Sousa PMF, Freire F, Bandeiras TM, Wienke D
2026
Bioproduction
An improved CRISPR-Cas9 protein-based method for knocking out insect Sf9 cell genes
Applied Microbiology and Biotechnology
Graça M, Virgolini N, Correia R, Escandell J, Roldão A
2026
Bioengineering for Cell-based Therapies
Scaling the manufacture of adipose tissue-derived mesenchymal stromal cells: integrated bioreactor workflows from inoculation to harvest without the need of seed train
BMC Biotechnology
Costa MHG, Terrasso AP, Crespo IE, Valero R, Menéndez B, Painho B, Sousa CD, Gamelas B, Tomás H, Mancheno‑Corvo P, Menta R, Gugel CR, Fernández‑Gómez V, Herrero‑Méndez Á, Mármol IZ, Avivar‑Valderas A, Pérez LM, Rosa O de la, Lombardo E, Serra M, Ortiz‑Virumbrales M
2026
Advanced Technologies for Gene Therapy Products
Enhancing gene therapy vectors manufacturing: CEBPA as a master regulator of rAAV biogenesis
Journal of Biological Engineering
Moura F, Antunes M, Correia R, Roldão A, Gomes‑Alves P, Alves PM, Escandell JM
2026
Advanced Technologies for Gene Therapy Products
Streamlined rAAV HeLaS3 producer cell line generation via GS selection
Scientific Reports
Antunes M, Moura F, Sebastian IR, Alves P, Gomes‑Alves P, Escandell JM
2026
Natural Bioactives & Nutraceuticals
Matching the Sensory Analysis of Serpa PDO Cheese with the Volatile Profiles—A Preliminary Study
Foods
Macedo A, Carvalho MJ, Mecha E, Costa L, Ferreira A, Inácio RS, Bronze MDR
2025
Natural Bioactives & Nutraceuticals
Impact of low-moisture extrusion on carbohydrate constituents and antinutrients of a blend of a faba bean protein concentrate and a beta-glucan enriched oat fraction
Food Research International
Saldanha do Carmo C, Mecha E, Schmidt G, Oliveira J, Bronze MR, Knutsen SH, Serra AT
2025
Advanced Technologies for Gene Therapy Products
Purification of AAV8 through a scalable two-step monolithic chromatography approach
Journal of Chromatography A
Nascimento A, Faria TQ, Bollmann F, Noverraz M, Pressac G, Roldão A, Peixoto C, Silva RJS
2025
Protein Biophysics for Drug Discovery
Pushing the limits of hydrogen/deuterium exchange mass spectrometry to study protein:fragment low affinity interactions
Communications Chemistry
Malta CF, Silva DO, Grädler U, Sousa PMF, Musil D, Schwarz D, Bomke J, Bandeiras TM, Bortoluzzi A
2025
Vaccines Bioprocess Engineering
Engineered thermoswitch in the baculovirus expression vector system for production of virus-like particle vaccines with minimized baculovirus contaminants
Trends in Biotechnology
van Oosten L, Altenburg JJ, Nowee G, Kenbeek D, Neef T, Rouw T, Tegelbeckers VIP, van der Heijden J, Mentink S, Willemsen W, Hausjell CS, Kuijpers L, van der Pol L, Roldão A, Correia R, van den Born E, Wijffels RH, Martens DE, van Oers MM, Pijlman GP
2025
Microbiology and Molecular Biology
Treatment of wastewater effluents using nanofiltration and low pressure UV photolysis to produce high quality water for food production
Water Research
Cristóvão MB, Sério J, Marques AP, Bento-Silva A, Gossard M, Vergara-Diaz O, Silva AF, Nunes M, Bronze MR, de Oliveira PB, Crespo MTB, Crespo JG, Pereira VJ
2025
Microbiology and Molecular Biology
Integration of spectroscopic techniques and machine learning for optimizing Phaeodactylum tricornutum cell and fucoxanthin productivity
Bioresource Technology
Reynolds-Brandão P, Quintas-Nunes F, Bertrand CF, Martins RM, Crespo MTB, Galinha CF, Nascimento FX
2025
Microbiology and Molecular Biology
From Dormancy to Eradication: Strategies for Controlling Bacterial Persisters in Food Settings
Foods
Serrano S, Grujović MŽ, Marković KG, Barreto-Crespo MT, Semedo-Lemsaddek T
2025
Vaccines Bioprocess Engineering
Virus-like particle vaccine with authentic quaternary epitopes protects against Zika virus-induced viremia and testicular damage
Journal of Virology
Abbo SR, Yan K, Geertsema C, Hick TAH, Altenburg JJ, Nowee G, van Toor C, van Lent JW, Nakayama E, Tang B, Metz SW, Bhowmik R, de Silva AM, Prow NA, Correia R, Alves PM, Roldão A, Martens DE, van Oers MM, Suhrbier A, Pijlman GP
2025
Protein Biophysics for Drug Discovery
Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor
Journal of Medicinal Chemistry
Mann SE, Lefranc J, Alkhatib O, Boivin R, Bomke J, Byrne RT, Cassona CP, Chen X, Cornaciu I, Costales P, Davis OA, DeSelm L, Elinati E, Follows B, Galbiati A, Göldner C, Hayre JK, Jorand-Lebrun C, Lademann CA, Leuthner B, Majithiya JB, Malta CF, Mason B, McWhirter CL, Neff B, Nissink JWM, Pehl U, Petersson C, Pica A, Pinto MF, Rajendra E, Rakers C, Toste Rêgo A, Robinson HMR, Sala-Hojman A, Schaedler TA, Schürmann PJL, Silva DO, Smith GCM, Sorrell F, Webster GR, Zenke FT, Heald RA, Burgdorf LT
2025
Microbiology and Molecular Biology
Beyond guaiacol and halophenols: Unravelling isobutyric and isovaleric acids as new culprits in off-flavour spoilage by Alicyclobacillus spp.
International Journal of Food Microbiology
Leonardo IC, Ferreira A, Bronze MR, Quendera AP, Fernandes AF, Barreto Crespo MT, Bustos Gaspar F
2025
Bioengineering for Cell-based Therapies
Controlled activation modulates T-cell expansion and phenotype in stirred-tank bioreactors
Cytotherapy
Costa MS, Costa CM, Matos LN, Sebastião MJ, Duarte N, Costa MHG, Serra M
2025
Natural Bioactives & Nutraceuticals
Optimization of Supercritical Fluid Extraction for the Recovery of γ-Oryzanol-Rich Extracts with Improved Bioactivity from Rice Bran
Antioxidants
Baixinho JP, Cardeira M, Bento-Silva A, Partidário AMC, Serra AT, Bronze MR, Fernández N
2025
Improving AAV8 purification with continuous affinity capture: From batch to continuous multicolumn chromatography
Journal of Biotechnology
Neto S, Rankine G, Bollmann F, Carrondo MJT, Silva RJS
2025
Natural Bioactives & Nutraceuticals
Storage Time in Bottle: Influence on Physicochemical and Phytochemical Characteristics of Wine Spirits Aged Using Traditional and Alternative Technologies
Molecules
Oliveira-Alves SC, Fernandes TA, Lourenço S, Granja-Soares J, Silva AB, Bronze MR, Catarino S, Canas S
2025
Vaccines Bioprocess Engineering
Continuous Production of Influenza VLPs Using IC‐BEVS and Multi‐Stage Bioreactors
Biotechnology and Bioengineering
Correia R, Zotler T, Ferraz F, Fernandes B, Graça M, Pijlman GP, Alves PM, Roldão A
2025