Publications

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Bioengineering for Cell-based Therapies
Scaling the manufacture of adipose tissue-derived mesenchymal stromal cells: integrated bioreactor workflows from inoculation to harvest without the need of seed train
BMC Biotechnology
Costa MHG, Terrasso AP, Crespo IE, Valero R, Menéndez B, Painho B, Sousa CD, Gamelas B, Tomás H, Mancheno‑Corvo P, Menta R, Gugel CR, Fernández‑Gómez V, Herrero‑Méndez Á, Mármol IZ, Avivar‑Valderas A, Pérez LM, Rosa O de la, Lombardo E, Serra M, Ortiz‑Virumbrales M
2026
Advanced Technologies for Gene Therapy Products
Enhancing gene therapy vectors manufacturing: CEBPA as a master regulator of rAAV biogenesis
Journal of Biological Engineering
Moura F, Antunes M, Correia R, Roldão A, Gomes‑Alves P, Alves PM, Escandell JM
2026
Advanced Technologies for Gene Therapy Products
Streamlined rAAV HeLaS3 producer cell line generation via GS selection
Scientific Reports
Antunes M, Moura F, Sebastian IR, Alves P, Gomes‑Alves P, Escandell JM
2026
Natural Bioactives & Nutraceuticals
Valorization of Olive Stones: Chemical Composition and Bioactivity
Pharmaceuticals
Nunes, Bruna and Fernández, Naiara and Bento Silva, Andreia and Partidário, Ana and Marto, Joana and Alexandre, Elisabete M. C. and Lourenço, Sofia and Serra, Ana Teresa and Bronze, Maria Rosário and Duarte, Noélia and Rodrigues, Ana Margarida
2026
Vaccines Bioprocess Engineering
Ferritin nanoparticles displaying rift valley fever virus glycoprotein elicit potent dendritic cell activation in vitro
Virology Journal
Rodrigues MQ, Cardoso I, Duarte N, Alves PM, Roldão A
2026
Microbiology and Molecular Biology
Sustainable Disinfection of Horticulture Industry Water Using UV-C Light-Emitting Diodes
Sustainability
Ferreira N, Marques AP, Silva MC, Barreto Crespo MT, Pereira VJ
2026
Advanced Technologies for Gene Therapy Products
Development of a serum-free producer cell line generation process for scalable and efficient rAAV production for gene therapy applications
Journal of Biotechnology
Escandell JM, Dias M, Gonçalves M, Pais D, Conceição A, Mathur A, Balva B, Sen S, Figueroa B, Vincent KA, Gomes-Alves P
2026
Protein Biophysics for Drug Discovery
Structure-based design of pyrazole derivatives targeting the human Cyclophilin D binding site
International Journal of Biological Macromolecules
Silva, Diana O. and Freitas, Micael C. and Malta, Catarina F. and Martins, Madalena T. and Sousa, Pedro M.F. and Matias, Pedro M. and Schwarz, Daniel and Ventura, M. Rita and Grädler, Ulrich and Bandeiras, Tiago M.
2026
Protein Biophysics for Drug Discovery
An integrative structural biology approach reveals the dynamic organization of the R2SP quaternary chaperone complex
Nature Communications
Santo PE, Chagot M‑E, Gizardin‑Fredon H, Ley M, Chenuel T, Deslignière E, Plassart L, Paiva ACF, Sousa PMF, Bertrand E, Charpentier B, Verheggen C, Quinternet M, Meyer P, Bandeiras TM, Cianférani S, Plisson‑Chastang C, Manival X
2026
Bioproduction
Evaluation of gene editing in CHO cells using the Cas-CLOVER system
Biotechnology Progress
McLamarrah T, Aral E, Hoffman M, Tedstone J, King T, Vitko J, Sebastião MJ, Escandell JM, Dias MM, McCall I, Machado D, Cairns V, DeMaria C, Scarcelli JJ
2026
Protein Biophysics for Drug Discovery
CNS penetrant TEAD1,2,4 inhibitor MSC-4070 derived from phenotypic screening hit optimization
RSC Medicinal Chemistry
Heinrich T, Petersson C, Gunera J, Gambardella A, Schwarz D, Garg S, Schilke H, Weitzel T, Kolb C, Anlauf U, Reither V, Rettig C, Opelt B, Delp A, Wildner N, Sousa PMF, Freire F, Bandeiras TM, Wienke D
2026
Bioproduction
An improved CRISPR-Cas9 protein-based method for knocking out insect Sf9 cell genes
Applied Microbiology and Biotechnology
Graça M, Virgolini N, Correia R, Escandell J, Roldão A
2026
Asparagopsis taxiformis Feed Supplementation as a Tool to Improve the Resilience of Farmed Diplodus sargus to Marine Heatwave Events—A Metabolomics Approach
Fishes
Dias M, Marmelo I, António C, Rodrigues AM, Marques A, Diniz MS, Maulvault AL
2025
Vaccines Bioprocess Engineering
Modifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune response in a mouse model
Communications Medicine
Renner TM, Stuible M, Rossotti MA, Rohani N, Cepero-Donates Y, Sauvageau J, Deschatelets L, Dudani R, Harrison BA, Baardsnes J, Koyuturk I, St. Michael F, Hill JJ, Hemraz UD, Lenferink AEG, Tanha J, Fernandes B, Roldao A, McCluskie MJ, Akache B, Durocher Y
2025
Advanced Cell Models for Drug Discovery and Translational Research
Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids
iScience
Gomes CM, Simão D, Gonçalves CC, Silva G, Painho B, Alves PM, Brito C
2025
High-throughput flow cytometry-based titration of a live attenuated rotavirus vaccine
Journal of Biotechnology
Dias MM, Carvalho SB, Matheise JP, Van Beersel G, Knott I, Gomes-Alves P, Alves PM
2025
Vaccines Bioprocess Engineering
Streamlined purification of ADDomer nanoparticles for scalable biomanufacturing
Journal of Biological Engineering
Arinto-Garcia R, Paiva CS, Dilla EB, Martens DE, Sargunas J, Betenbaugh M, Buzas D, Balchin G, Moleirinho M, Castro R, Peixoto C, Berger I, Schaffitzel C, Alves PM, Roldão A
2025
Advanced Technologies for Gene Therapy Products
Deciphering key parameters enhancing lentiviral vector producer cells yields: Vector components copy number and expression
Molecular Therapy Methods & Clinical Development
Formas-Oliveira AS, Ferreira MV, Coroadinha AS
2025
Vaccines Bioprocess Engineering
Baculovirus-mediated production and purification of ferritin nanoparticles for rift valley fever vaccine development
Journal of Biological Engineering
Rodrigues MQ, Tambaclal A, Kloss B, Alves PM, Roldão A
2025
Natural Bioactives & Nutraceuticals
Antibacterial and Antifungal Activity of Extracts from Five Portuguese Cowpea (Vigna unguiculata) Accessions
Molecules
Salamandane A, Candeias M, Lourenço S, Vieira EJF, Mecha E, Gomes R, Bronze R, Nunes C, Brito L
2025
Bioanalytics
Multispecific antibodies: Bioanalytics for early-stage screening and characterization of mispairing profiles
PLOS One
Melo C, Carvalho SB, Sebastião MJ, Gomes RA, Sousa PMF, Gomes-Alves P
2025
Bioengineering for Cell-based Therapies
Billion‐Scale Expansion of Functional hiPSC‐Derived Cardiomyocytes in Bioreactors Through Oxygen Control and Continuous Wnt Activation
Advanced Science
Vicente P, Inocêncio LR, Ullate‐Agote A, Louro AF, Jacinto J, Gamelas B, Iglesias‐García O, Martin‐Uriz PS, Aguirre‐Ruiz P, Ríos‐Muñoz GR, Fernández‐Santos ME, van Mil A, Sluijter JPG, Prósper F, Mazo MMV, Alves PM, Serra M
2025
Advanced Cell Models for Drug Discovery and Translational Research
3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV
Scientific Reports
Ramella Gal I, Arez F, Correia IP, Domenici G, Fernandes S, Silva G, Saldanha I, Duarte N, Freitas C, Alves PM, Maier U, Coroadinha AS, du Plessis F, Brito C
2025
Advanced Cell Models for Drug Discovery and Translational Research
Sustained Macrophage Reprogramming Is Required for CD8+ T cell–Dependent Long-Term Tumor Eradication
Cancer Immunology Research
Jardim C, Bica M, Reis-Sobreiro M, Teixeira da Mota A, Lopes R, Pinto MF, Sousa NS, Mensurado S, Boekhoff H, Scolaro T, Reugebrink M, Goncalves-Sousa N, Kubo H, Gomes CM, Brito C, Argüello RJ, Leites EP, Morais VA, Silva-Santos B, Barbosa-Morais NL, Serre K
2025