Cell Line Development and Molecular Virology Lab

Development and engineering of virus-based biopharmaceuticals for gene therapy and vaccines.

Research Focus

The Cell Line Development and Molecular Virology (CLD&MV) lab combines interdisciplinary expertise and competences in molecular and cell biology, virology, and animal cell culture technology.

Our research is anchored on applied virology to advance the development of Advanced Therapy Medicinal Products (ATMPs) for gene therapy applications.

Our core areas of activity range from the design of novel recombinant viruses or viral particles; the development of expression systems for biomanufacturing; cell line engineering; and the development of enabling tools for virus research. The tools developed are applied in research projects in drug-discovery, vaccines and antiviral therapies.

Areas of Activity

Design and Development of Expression Systems for Biomanufacturing

Design and construction of the genetic cassettes for protein and virus expression using advanced molecular biology tools (for transient, viral mediated or stable expression)

Cell Line Development

Establishment of novel cell lines or genetic enhancement of cell substrates through stable expression, knockout or knockdown, and clonal screening

Recombinant Virus Design and Engineering

Design and genetic enhancement of recombinant viruses and particles (e.g. based on lentivirus, adeno-associated virus, adenovirus) to improve the product therapeutic efficacy (specificity, tropism, transduction efficiency, immune response)

Development of Enabling Tools for Virus Research

Development of genetic tools and methods to detect, quantify and characterize viruses and viral particles (e.g. biosensors for virus detection and quantification) in the context of research projects in drug-discovery, vaccines and antiviral therapies.

Design and development of expression systems for biomanufacturing
Cell line development

Team Members